372-39-4 | 3,5-Difluoroaniline

CAS:372-39-4 | 3,5-Difluoroaniline,Description

Synthesis Analysis

The synthesis of 3,5-Difluoroaniline has been explored through various methods, highlighting its accessibility for chemical studies and industrial applications. Feng Ya-qing (2004) discussed ten synthetic routes from different raw materials, emphasizing methods using m-phenylene diamine and 2,4-difluoroaniline as promising for industrial applications in China (Feng Ya-qing, 2004).

Molecular Structure Analysis

The molecular structure and conformation of 3,5-Difluoroaniline have been detailed through experimental and theoretical studies. Pathak et al. (2015) conducted a comprehensive investigation using FT-IR, FT-Raman, UV, and NMR spectroscopies, alongside DFT calculations, revealing insights into the molecular properties such as dipole moment, polarizability, and molecular electrostatic potential surface (Pathak et al., 2015).

Chemical Reactions and Properties

The chemical reactions and properties of 3,5-Difluoroaniline showcase its reactivity and stability, influenced by charge delocalization and electronic properties. The study by Pathak et al. (2015) also highlighted the molecule's stability from charge delocalization and reactivity descriptors, providing a foundation for understanding its chemical behavior (Pathak et al., 2015).

Physical Properties Analysis

The physical properties of 3,5-Difluoroaniline, such as spectroscopic characteristics and thermodynamic properties, were evaluated, offering a deeper understanding of its behavior under various conditions. Pathak et al.'s (2015) work provided valuable data on its thermodynamic properties, contributing to the comprehensive profile of this compound (Pathak et al., 2015).

Chemical Properties Analysis

The chemical properties, including reactivity and stability, were extensively analyzed through natural bond orbital (NBO) analysis and reactivity descriptors. This analysis underscores the compound's potential for various chemical reactions and applications, as detailed in the studies by Pathak et al. (2015) (Pathak et al., 2015).

Scientific Research Applications

• Thermophysical Property Data Analysis

  • Application : 3,5-Difluoroaniline is used in the generation of thermodynamic property data. These data are critically evaluated and are used for various scientific and industrial applications.
  • Method : The data are generated through dynamic data analysis, as implemented in the NIST ThermoData Engine software package.
  • Results : The data include properties such as triple point temperature, normal boiling temperature, critical temperature, critical pressure, and density among others.

• In Vitro Nephrotoxic Effects Study

  • Application : 3,5-Difluoroaniline has been used in biomedical research to study its nephrotoxic effects in vitro.
  • Method : The nephrotoxic effects of 3,5-difluoroaniline were investigated in renal cortical slices obtained from the kidneys of untreated, male Fischer 344 rats.
  • Results : The specific results of this study are not provided in the source.
• Production of Derivatives
  • Application : 3,5-Difluoroaniline is used in the production of its derivatives. These derivatives can be used as intermediate products for pharmaceuticals.
  • Method : The production process involves reacting an aminating agent with a 1,3,5-trifluorobenzene compound.
  • Results : The process results in the production of a 3,5-difluoroaniline compound with ease.

• Preparation of 3,5-Difluorodimethylaniline

  • Application : 3,5-Difluoroaniline has been used in the preparation of 3,5-difluorodimethylaniline.
  • Method : The specific method of preparation is not provided in the source.
  • Results : The process results in the production of 3,5-difluorodimethylaniline.

• Laboratory Chemicals

  • Application : 3,5-Difluoroaniline is used as a laboratory chemical.
  • Method : The specific method of application is not provided in the source.
  • Results : The specific results of this application are not provided in the source.

Safety And Hazards

3,5-Difluoroaniline is harmful if swallowed, in contact with skin, or if inhaled. It causes skin and eye irritation and may cause respiratory irritation. It’s recommended to avoid dust formation, breathing mist, gas, or vapors, and contact with skin and eyes. Use personal protective equipment and ensure adequate ventilation.

More Information

Synthesis