373-88-6 | 2,2,2-Trifluoroethylamine hydrochloride

CAS:373-88-6 | 2,2,2-Trifluoroethylamine hydrochloride ,Description

2,2,2-Trifluoroethylamine hydrochloride (TFA-HCl) is a widely used reagent in chemical and biological laboratories. It is a colorless liquid that is soluble in water and miscible with most organic solvents. TFA-HCl has a wide range of applications in synthetic chemistry, and is also used in biochemical and physiological research. 
 

Scientific Research Applications

• Building Block for Synthesis

  It's a promising building block for the efficient synthesis of 2-acylamino-2-trifluoromethylethanol (Tanaka, Ishiguro, & Mitsuhashi, 1993).

• N-trifluoroethylation of Anilines

  Iron porphyrin-catalyzed N-trifluoroethylation of anilines with 2,2,2-trifluoroethylamine hydrochloride in aqueous solution provides a wide range of N-trifluoroethylated anilines in good yield (Ren et al., 2021).

• Synthesis of Fluorinated Aroxysulfonyl Ureas

  Addition of 2,2,2-trifluoroethylamine in toluene and F-alkylamines without solvent to aroxysulfonyl isocyanates effectively prepares fluorinated aroxysulfonyl ureas with high yields (Kateb, Beji, & Baklouti, 1999).

• Diastereoselective Synthesis

  Diastereoselective synthesis of 1-aryl-2,2,2-trifluoroethylamines using 2-methyl-N-(2,2,2-trifluoroethylidene)propane-2-sulfinamide enables the synthesis (Truong, Ménard, & Dion, 2007).

• Perovskite Solar Cells

  Fluoroethylamine passivation in perovskite solar cells improves efficiency and stability, achieving up to 23.40% efficiency and 87% initial efficiency after 1200 hours of exposure (Su et al., 2021).

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