374-01-6 | 1,1,1-Trifluoro-2-propanol

CAS:374-01-6 | 1,1,1-Trifluoro-2-propanol ,Description

1,1,1-Trifluoro-2-propanol (TFP) is a colorless, volatile liquid with a low boiling point and a low melting point. It is an important intermediate in the synthesis of many compounds, including pharmaceuticals, agrochemicals, and fragrances. TFP is widely used in the laboratory and industrial settings due to its low toxicity and low reactivity. It is also used as a solvent in the production of polymers and other materials.
 

Scientific Research Applications

• Infrared Spectroscopy and Hydrogen Bonding Studies

  • 1,1,1-Trifluoro-2-propanol has been studied for its unique hydrogen bonding characteristics. Infrared spectroscopy revealed dimers, oligomers, and large clusters in this compound, providing insights into hydrogen bond strength and cluster stability trends. This compound is useful for understanding intramolecular torsional isomerization dynamics (Schaal, Häber, & Suhm, 2000).

• Organic Synthesis and Chemical Reactions

  • It plays a pivotal role in regio- and diastereoselective ring-opening reactions, particularly in synthesizing cholesteryl ester transfer protein (CETP) inhibitors (Li et al., 2010) .
  • 1,1,1-Trifluoro-2-propanol is involved in the synthesis of heterocyclic compounds, acting as a key component in various chemical reactions (Kamitori, 2003).

• Miscibility Studies with Water

  • Its interaction with water has been explored using molecular dynamics simulations. This research offers insights into the physicochemical properties of fluorinated organic molecules (Fioroni, Burger, Mark, & Roccatano, 2003).

• Application in Photodissociation Dynamics

  • Studies on the photodissociation dynamics of 3-bromo-1,1,1-trifluoro-2-propanol provide valuable information on the energy distribution and molecular behavior under specific conditions (Indulkar et al., 2011).

• Catalysis in Organic Reactions

  • This compound has been used as a catalyst in organic reactions such as the synthesis of tris(indolyl)methanes, demonstrating its versatility in chemical synthesis (Khaksar, Vahdat, Gholizadeh, & Mohammadzadeh Talesh, 2012).

• Use in Ruthenium-Catalyzed Hydrogenation

  • It is an important reactant in the enantioselective synthesis of trifluoroalkan-2-ols, showcasing its role in precise and controlled chemical reactions (Kuroki, Asada, Sakamaki, & Iseki, 2000).

• Environmental and Physicochemical Properties

  • Its adsorption states on silicon surfaces have been investigated, highlighting its importance in surface science and materials chemistry (Nagao et al., 2003).
  • The compound is also studied in the context of CO2 fixation and transformation into cyclic carbonates, demonstrating its environmental applications (Ma et al., 2020).

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