375-16-6 | Heptafluorobutyryl chloride

CAS:375-16-6 | Heptafluorobutyryl chloride ,Description

Heptafluorobutyryl chloride (HFBC) is a halogenated organofluorine compound that is widely used as a reagent in organic synthesis and analytical chemistry. It is a colorless, volatile liquid with a pungent odor. It is highly reactive and often used as a catalyst for many chemical reactions. HFBC has been used in a variety of applications, including the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used in the production of polymers, surfactants, and other specialty chemicals. 
 

Scientific Research Applications

Chromatographic Analysis and Mass Spectrometry

Heptafluorobutyryl chloride is widely used in gas chromatography and mass spectrometry for the analysis of various compounds. Bakthavachalam et al. (1990) utilized it in the preparation of electrophoric derivatives for the determination of aminopolyaromatics using gas chromatography with electron-capture negative-ion mass spectrometry. This approach allowed for the sensitive detection of these compounds (Bakthavachalam et al., 1990). Similarly, Mackenzie and Tenaschuk (1974) employed N-heptafluorobutyryl isobutyl esters in the chromatographic separation of protein amino acids, demonstrating its utility in protein analysis (Mackenzie & Tenaschuk, 1974).

Derivatization of Chemicals

Niitsu et al. (1993) explored heptafluorobutyryl derivatives for the systematic analysis of linear and branched polyamines. Their study highlighted the distinct fragmentation patterns and chromatographic properties of these derivatives (Niitsu et al., 1993). Bailey et al. (1978) focused on the derivatization of triazine herbicides using heptafluorobutyryl derivatives, which significantly enhanced their detection sensitivity (Bailey et al., 1978).

Synthesis and Chemical Analysis

Hwang et al. (2007) conducted a study on the synthesis of methoxy and ethoxy nonafluorobutanes, where heptafluorobutyryl chloride played a crucial role in the reaction process (Hwang et al., 2007). Ryan and Lawrence (1977) compared the chromatographic characteristics of heptafluorobutyryl derivatives of agricultural chemicals, providing insights into their analytical applications (Ryan & Lawrence, 1977).

Derivatization in Mass Spectrometry

Mikaya et al. (1988) developed a methodology for investigating amines, including acylation in a chromato-mass spectrometer column with heptafluorobutyryl chloride. This approach was significant for the analysis of primary and secondary amines (Mikaya et al., 1988).

Hair Sample Analysis

Li et al. (2008) devised a method for determining polyamines in hair as N-heptafluorobutyryl derivatives, showcasing the utility of heptafluorobutyryl chloride in bioanalytical studies (Li et al., 2008).

More Information