379-95-3 | Dimethyl difluoromalonate

CAS:379-95-3 | Dimethyl difluoromalonate ,Description

Dimethyl difluoromalonate (DMDFM) is an organofluorine compound that is widely used in organic synthesis. It is used in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. DMDFM is a colorless liquid with a boiling point of 108°C and a melting point of -18°C. It is a highly reactive compound with a strong electrophilic character and is used in a variety of synthetic processes.
 

Scientific Research Applications

Antifungal Properties

• Dimethyl Itaconate in Fungal Keratitis Treatment: Dimethyl itaconate, a derivative with similarities to dimethyl difluoromalonate, has shown protective effects against fungal keratitis. This compound acts by activating the Nrf2/HO-1 signaling pathway, reducing inflammation and fungal growth in infected corneas (Gu et al., 2020).

Chemical Synthesis and Transformations

• Electrochemical Fluorination of Esters: The electrochemical fluorination of dimethyl or diethyl esters of dicarboxylic acids, which includes compounds like dimethyl difluoromalonate, has been studied. This process yields various fluorinated compounds, demonstrating the utility of dimethyl difluoromalonate in synthetic chemistry (Nagase et al., 1968).

Molecular and Cellular Research

• Dimethyl Sulfoxide in Cellular Processes: Although not directly about dimethyl difluoromalonate, related research on dimethyl sulfoxide shows its role in affecting cellular processes and macromolecules, which may provide insights into similar small molecule interactions (Tunçer et al., 2018) .

Pharmaceutical Research

• Bibliometric Evaluation of Dimethyl Fumarate Articles: While focusing on dimethyl fumarate, this bibliometric study shows the broad interest and applications of similar dimethyl compounds in various research fields, potentially extending to dimethyl difluoromalonate (García-Fernández et al., 2021) .

Educational Applications

• Use in Physical Chemistry Experiment Teaching: Dimethyl compounds, akin to dimethyl difluoromalonate, are used in educational settings to illustrate chemical synthesis and characterization, as seen in a study involving the synthesis of dimethyl carbonate (He De-hua et al., 2006).

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