381-73-7 | Difluoroacetic acid

CAS:381-73-7 | Difluoroacetic acid ,Description

Difluoroacetic acid (DFA) is an organic acid with two fluorine atoms bonded to a carboxylic acid group. It is a colorless, volatile, and flammable liquid at room temperature and is soluble in water and other organic solvents. DFA has a wide range of applications in the fields of chemistry and biology, including in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. It is also used as a reagent in various biochemical and physiological processes. In 
 

Scientific Research Applications

Copper-Catalyzed Allylic Difluoromethylation

• Application: DFA is used in a copper-catalyzed allylic difluoromethylation of unactivated alkenes, offering a straightforward method for constructing allylic CF2H bonds. This reaction employs readily available alkenes and DFA under mild conditions, highlighting DFA's utility in organic synthesis (Wang et al., 2023).

Hydrodifluoromethylation of Alkenes

• Application: DFA is utilized in the regioselective hydrodifluoromethylation of alkenes. This method is notable for using inexpensive reagents and displaying broad functional group tolerance, making it a valuable tool in medicinal chemistry (Meyer et al., 2019).

Photodissociation Studies

• Application: DFA's photodissociation dynamics are studied in both ground and excited electronic states. These studies are crucial for understanding the molecular behavior of DFA under various conditions, which can have implications in environmental chemistry and atmospheric studies (Kumar et al., 2004).

Chemical Synthesis

• Application: DFA serves as a reagent in chemical synthesis, like in the direct C-H difluoromethylation of heteroaromatic compounds. This highlights its role in facilitating complex chemical transformations, useful in drug discovery and chemical biology (Tung et al., 2017).

Environmental Studies

• Application: DFA is investigated in environmental contexts, such as its formation in chlorofluorocarbon-contaminated ground water. This research is important for understanding the environmental impact and behavior of industrial chemicals (Dorgerloh et al., 2019).

Role in Analytical Chemistry

• Application: DFA is used as an additive in liquid chromatography-mass spectrometry of peptides and proteins. Its influence on the analytical techniques underscores its importance in bioanalytical studies (Nshanian et al., 2017).

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