381-88-4 | 1,1,1-Trifluoro-2-butanone

CAS:381-88-4 | 1,1,1-Trifluoro-2-butanone ,Description

1,1,1-Trifluoro-2-butanone, also known as TFB or 2-Butanone, Trifluoro, is an organic compound belonging to the class of ketones. It is an important intermediate in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals. It is a colorless, volatile liquid with a sweet, ether-like odor and a boiling point of 41.5°C. The molecular formula for TFB is C4H5F3O and its molecular weight is 122.08 g/mol.
 

Scientific Research Applications

Rotational Spectrum Analysis

1,1,1-Trifluoro-2-butanone's rotational spectra, including those of its isotopologues, have been extensively studied using chirped-pulse Fourier transform microwave spectroscopy. This research aids in understanding the molecule's structure, stability, and internal rotational dynamics, which are crucial for applications in physical chemistry and molecular physics (Evangelisti, Sedo, & van Wijngaarden, 2011).

Organic Synthesis and Structural Analysis

The compound has been used in organic synthesis, particularly in the formation of specific alcohols and esters. For example, its reduction with lithium aluminium hydride yields trifluoro alcohols, important in organic synthesis and pharmaceuticals (Faure, Felix, Laurent, & Mišoň, 1997).

Radioactive Synthesis

In radiopharmaceuticals, 1,1,1-Trifluoro-2-butanone has been used in the synthesis of carbon-14 labeled compounds, which are critical in medical diagnostics and biological research (Dischino, Banville, & Rémillard, 2003) .

Biochemical Production

The biochemical production of 2-butanone, a derivative of 1,1,1-Trifluoro-2-butanone, has been achieved by genetically engineering Klebsiella pneumoniae. This advancement opens up possibilities in biotechnology for producing chemicals from renewable resources (Chen, Sun, Huang, Wu, & Liu, 2015).

Biofuel Research

1,1,1-Trifluoro-2-butanone has potential applications in biofuel research, especially regarding its derivatives like 2-butanone. Studies have shown promising results in terms of combustion stability and efficiency when used in spark ignition engines, highlighting its potential as a sustainable fuel alternative (Hoppe, Burke, Thewes, Heufer, Kremer, & Pischinger, 2016).

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