382-34-3 | 1,1,2,3,3,3-Hexafluoropropyl methyl ether

CAS:382-34-3 | 1,1,2,3,3,3-Hexafluoropropyl methyl ether ,Description

1,1,2,3,3,3-Hexafluoropropyl methyl ether (HFPME) is an ether compound that is widely used in a variety of scientific research applications. It is a colorless liquid with a sweet odor, and it is miscible with water and many organic solvents. HFPME is a versatile compound that has a wide range of applications in synthetic chemistry, organic synthesis, and chromatography.
 

Scientific Research Applications

Metabolism and Chemical Transformation

1,1,2,3,3,3-Hexafluoropropyl methyl ether is developed as an alternative to replace ozone-depleting chlorofluorocarbons. In a study, its metabolism was analyzed in rat and human liver microsomes, where it was metabolized to inorganic fluoride and formaldehyde, and 2,3,3,3-Tetrafluoropropionic acid was identified as a metabolite. The study highlighted the involvement of cytochrome P450 2E1 in its metabolism (Köster et al., 1994) .

Vapor Pressure Measurement

The vapor pressures of fluoroethers, including 1,1,2,3,3,3-hexafluoropropyl methyl ether, were measured at various temperatures using a gas stripping method. This study is important for understanding the physical properties of fluoroethers under different temperature conditions (Fukuchi et al., 2004).

Halogen-Exchange Reactions

Fluoromethyl 1,1,2,3,3,3-hexafluoropropyl ether was found to be a selective fluoride donor in some halogen-exchange reactions. This study highlights the potential application of this compound in selective chemical syntheses (Rozov et al., 1998).

Electrolyte Enhancement in Lithium-Ion Batteries

A study on the role of a partially fluorinated ether (PFE) based on a mixture including 1,1,2,3,3,3-hexafluoropropyl methyl ether examined its impact on the oxidative durability of electrolytes under high-voltage conditions in lithium-ion batteries. This research suggests its application in improving the performance of high-voltage lithium-ion batteries (Kim et al., 2017).

Industrial Production

A novel method for the industrial production of 1,1,1,3,3,3-hexafluoroisopropyl methyl ether using vapor-phase catalysis was developed, showcasing its potential for mass production as a substitute for ozone-depleting substances. This approach is significant for environmental sustainability (Li et al., 2020).

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