383-62-0 | Ethyl chlorodifluoroacetate

CAS:383-62-0 | Ethyl chlorodifluoroacetate ,Description

Ethyl chlorodifluoroacetate (ECF) is a highly toxic chemical compound that is used in a variety of scientific and industrial applications. ECF is a colorless, volatile liquid with an acrid odor and is a member of the chlorofluorocarbon family. ECF is used primarily in the synthesis of pharmaceuticals and pesticides, as well as in the production of polyurethane foam and other polymers. ECF is also used in the manufacture of dyes and as a solvent for organic compounds. In addition, ECF has been used in laboratory experiments to study the biochemistry and physiology of organisms.
 

Scientific Research Applications

Atmospheric and Environmental Studies

Ethyl chlorodifluoroacetate (ECDFA) has been extensively studied in the context of atmospheric chemistry. Blanco et al. (2016) conducted a comprehensive study on the atmospheric sink of ECDFA, investigating its reaction with chlorine atoms. This research provided valuable insights into the reaction kinetics and product distribution of ECDFA in the atmosphere. The study showed that ECDFA primarily reacts with chlorine atoms to form chlorofluorocarboxylic acid, a compound with significant atmospheric implications (Blanco, Barnes, Wiesen, & Teruel, 2016).

Chemical Synthesis

Ethyl chlorodifluoroacetate is also an important reagent in chemical synthesis. Czaban-Jóźwiak, Loska, and Mąkosza (2016) utilized ECDFA in the synthesis of α-fluoro-α-nitroarylacetates, demonstrating its utility in creating complex organic molecules. This process involves the formation of an α-chloro-α-fluorocarbanion, which adds to nitroarenes to produce ethyl α-fluoro-α-nitroarylacetates, highlighting its versatility in synthetic chemistry (Czaban-Jóźwiak, Loska, & Mąkosza, 2016) .

Organic Chemistry and Material Science

In organic chemistry, Tsukamoto and Kitazume (1993) explored the use of ECDFA in the preparation and reaction of difluorinated malonaldehydic acid derivatives. Their research contributed to the development of new routes to synthesize α,α-difluorinated esters and amides, demonstrating ECDFA's role in expanding the repertoire of fluorinated compounds (Tsukamoto & Kitazume, 1993).

Environmental Toxicology

ECDFA's environmental impact, particularly on aquatic systems, has been a subject of study. Hanson et al. (2001) investigated the fate and toxicity of chlorodifluoroacetic acid (a related compound) in aquatic microcosms, focusing on its effects on macrophytes such as Lemna gibba and Myriophyllum species. This research is crucial in understanding the environmental behavior and potential risks of ECDFA and its derivatives (Hanson, Sibley, Mabury, Muir, & Solomon, 2001).

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