3871-99-6 | Potassium perfluorohexanesulfonate

CAS:3871-99-6 | Potassium perfluorohexanesulfonate ,Description

Potassium perfluorohexanesulfonate (KPFHS) is a water-soluble surfactant and anionic detergent that is widely used in the synthesis of pharmaceuticals, biochemicals, and other organic compounds. It is a colorless, odorless, and non-toxic compound that has a wide range of applications due to its unique properties. KPFHS is a highly efficient surfactant that is used in various industrial and laboratory processes. It has a low critical micelle concentration (CMC) and is capable of forming stable micelles even at low concentrations. Furthermore, KPFHS is also used as an emulsifier, dispersant, and solubilizer in various applications.
 

Scientific Research Applications

Toxicological Evaluations

• Reproductive and Developmental Toxicity in Mice: Potassium perfluorohexanesulfonate (K+PFHxS) was evaluated for reproductive and developmental toxicity in CD-1 mice, where it showed an equivocal decrease in live litter size and adaptive hepatocellular hypertrophy without significant effects on reproductive parameters, hematology, neurobehavioral effects, or histopathology (Chang et al., 2018).
• Comparative Analysis of Perfluorooctanesulfonate (PFOS) Samples: Studies on samples of potassium perfluorooctanesulfonate (PFOSK) from different suppliers indicated varying purity and percentages of linear isomer, providing insights into the complex compositions of these compounds (Arsenault et al., 2008).
• 90-Day Oral Gavage Study with Rats: Evaluation of potassium perfluorobutanesulfonate (K+PFBS) in rats revealed dose-dependent effects, including histopathological changes in the stomach and kidneys, suggesting potential toxicological concerns (Lieder et al., 2009).

Environmental Impact Assessments

• Perfluorooctanesulfonate in Human Blood: A study on perfluorooctanesulfonate and related fluorochemicals in human blood from various countries highlighted their persistent and bioaccumulative nature, indicating widespread environmental exposure (Kannan et al., 2004).
• Reproductive and Developmental Toxicity in Rats: Research on the potential reproductive and developmental toxicity of perfluorohexanesulfonate (PFHxS) in rats showed no reproductive or developmental effects under study conditions, contributing to the understanding of its impact on environmental health (Butenhoff et al., 2009).
• Developmental Neurotoxicity in Rats: Gestational and lactational exposure to potassium perfluorooctanesulfonate (K+PFOS) in rats was studied for developmental neurotoxicity, revealing no significant effect on maternal health or reproductive outcomes, but some neurobehavioral changes were observed (Butenhoff et al., 2009).

Analytical Method Development

• Quantification of Perfluorochemicals in Blood: A method was developed for the determination of PFOS and related perfluorochemicals in human whole blood, providing a tool for assessing human exposure to these compounds (Kärrman et al., 2005) .
• Two-Generation Oral Gavage Study in Rats: Potassium perfluorobutanesulfonate (K+PFBS) was studied in a two-generation reproduction rat study, which included various health endpoints, contributing to the risk assessment of these substances (Lieder et al., 2009).
• Survey of Perfluorinated Acids in Oceans: A global survey of perfluorinated acids in oceans underscored the environmental spread and persistence of these compounds, demonstrating their potential ecological impact (Yamashita et al., 2005).

More Information