392-56-3 | Hexafluorobenzene

CAS:392-56-3 | Hexafluorobenzene ,Description

Hexafluorobenzene (HFB) is an organic compound that belongs to the family of perfluorinated compounds. It is a colorless, volatile liquid with a sharp, sweet odor. It has a wide range of applications in the fields of chemistry, biochemistry, and material science. It is an important intermediate for the synthesis of various organic compounds, such as pharmaceuticals, dyes, and pigments. In addition, it has been used in the synthesis of polymers, surfactants, and other materials.
 

Scientific Research Applications

• Anesthetic Potential: Hexafluorobenzene was examined for possible use in anesthesia due to its anesthetic properties in mice, as indicated in studies on cats (Garmer & Leigh, 1967).
• Dielectric Etch Chemistry: It has been evaluated as an environmentally benign alternative for dielectric etch applications in high density plasma etch chambers, with potential for significant reductions in global warming emissions (Chatterjee et al., 2001).
• Photochemistry and Fluorocarbon Production: Hexafluorobenzene demonstrates unique capabilities in photochemistry, serving as a source for a variety of highly fluorinated compounds and fluorocarbon derivatives upon ultraviolet irradiation (Lemal, 2001).
• Nuclear Reactor Cooling Fluid: It is used as a cooling fluid in nuclear reactors. Studies on its behavior under extreme conditions and high pressure have been conducted to understand its phase transitions and molecular dynamics (Mohan et al., 2021).
• Biomedical Research: In biomedical research, hexafluorobenzene has been used for monitoring tumor oxygen tension dynamics via 19F NMR relaxometry (Mason et al., 2003).
• Peptide Cyclisation and Stapling: It has been studied for its reaction capabilities in peptide cyclisation and stapling, showing potential as a disulfide crosslinking reagent (Dognini et al., 2020).
• Charge Transfer Complexes: Its role as an electron acceptor in forming charge transfer complexes with aromatic amines has been investigated, which is significant in understanding molecular interactions (Beaumont & Davis, 1968).
• Solvation-Induced Fluorescence Enhancement: Research shows that hexafluorobenzene can strongly solvate certain molecular structures, leading to enhanced fluorescence and conformational confinement, which is important in understanding photoelectronic properties (Morisue et al., 2017).
• Radiolabeling in Biomedical Imaging: It has been modified for radiolabeling and dimerizing thiolated peptides, offering novel approaches in imaging and diagnosis (Jacobson et al., 2015).
• Study of Excited States and Triplet States: Research into the photochemistry of hexafluorobenzene in the vapor phase provides insights into its excited singlet and triplet states, which is significant in understanding its photophysical behavior (Phillips, 1967).

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