394-04-7 | 5-FLUORO-2-METHOXYBENZOIC ACID

CAS:394-04-7 | 5-FLUORO-2-METHOXYBENZOIC ACID,Description

5-Fluoro-2-methoxybenzoic acid is a chemical compound with the molecular formula C8H7FO3¹. It is an off-white powder5-Fluoro-2-methoxybenzoic acid is a chemical compound with the molecular formula C8H7FO31" h="ID=SERP,5015.1">².

Synthesis Analysis

The synthesis of 5-Fluoro-2-methoxybenzoic acid involves several steps. One method involves nitration, reduction, diazotization, and hydrolysis of 5-fluoro-2-methylbenzoic acid². Another method involves sequential bromination, azido replacement, and reduction².
 

Molecular Structure Analysis

The molecular structure of 5-Fluoro-2-methoxybenzoic acid consists of 8 carbon atoms, 7 hydrogen atoms, 1 fluorine atom, and 3 oxygen atoms³⁴⁵.
 

Chemical Reactions Analysis

The exact chemical reactions involving 5-Fluoro-2-methoxybenzoic acid are not fully elucidated. However, it is known that it can undergo nitration, reduction, diazotization, and hydrolysis².
 

Physical And Chemical Properties Analysis

5-Fluoro-2-methoxybenzoic acid has a molecular weight of 170.14 g/mol⁶. It has a density of 1.3±0.1 g/cm3, a boiling point of 294.0±20.0 °C at 760 mmHg, and a flash point of 131.6±21.8 °C5-Fluoro-2-methoxybenzoic acid has a molecular weight of 170.14 g/mol6" h="ID=SERP,5015.1">⁷. It is insoluble in water¹.
 

Scientific Research Applications

Synthesis and Chemical Applications

• Insecticidal Activity Synthesis : 5-Fluoro-2-methoxybenzoic acid is utilized in the synthesis of certain 1,3,4-oxadiazoles, which have shown low insecticidal activity against crop pests. This synthesis involves a series of reactions including esterification and hydrazinolysis (Mohan, Vishalakshi, Bhat, Rao, & Kendappa, 2004) .
• Radioligand Synthesis for Brain Receptors : It has been used in the synthesis of compounds like 4‐(4‐([11C]methoxyphenyl)‐(5‐fluoro‐2‐hydro‐xyphenyl)‐methylene‐aminobutyric acid, potentially serving as radioligands for GABA receptors in the brain (Vos & Slegers, 1994) .

Material Science and Engineering

• Liquid Crystals Synthesis : 5-Fluoro-2-methoxybenzoic acid is used in the creation of liquid crystals. For example, its derivatives have been synthesized and characterized for their mesomorphic properties, influencing the development of advanced materials (Li, Yu, Liu, & Wen, 2010) .

Medical and Biological Research

• PET Cancer Imaging Agents : Carbon-11 labeled fluorinated 2-arylbenzothiazoles, synthesized using derivatives of 5-Fluoro-2-methoxybenzoic acid, may serve as probes in PET scans to image tyrosine kinase in cancers, showing potential in cancer diagnostics (Wang, Gao, Mock, Miller, Sledge, Hutchins, & Zheng, 2006).

Environmental Science

• Detection of Aromatic Metabolites : This compound has been utilized in environmental studies, such as detecting aromatic metabolites from m-Cresol in a methanogenic consortium. This aids inunderstanding microbial degradation pathways, crucial for environmental biotechnology applications (Londry & Fedorak, 1993).

Pharmaceutical Research

• Chemosensor Development : 5-Fluoro-2-methoxybenzoic acid derivatives have been used in creating chemosensors for detecting copper ions. This has implications in bioimaging and can be applied in various medical and environmental fields (Gao, Yang, Huo, Yin, Xu, Zhang, Chao, Jin, & Zhang, 2014).

Organic Chemistry

• Synthesis of Organic Compounds : The compound is employed in the synthesis of various organic compounds, like Methyl 4-Bromo-2-methoxybenzoate, highlighting its versatility in organic synthesis processes (Chen Bing-he, 2008).

Plant Protection and Agriculture

• Plant Disease Control : Its derivatives have shown potential in inducing systemic acquired resistance in plants, which can be a target for developing new plant protection agents. This is significant for agricultural research and development (Silverman, Petracek, Heiman, Fledderman, & Warrior, 2005).

Safety And Hazards

5-Fluoro-2-methoxybenzoic acid is considered hazardous. It can cause skin irritation, serious eye irritation, and may cause respiratory irritation⁸⁹. It is recommended to avoid breathing dust/fume/gas/mist/vapors/spray and to use only outdoors or in a well-ventilated area¹⁰.

Future Directions

The future directions for the use and study of 5-Fluoro-2-methoxybenzoic acid are not clearly defined in the literature.

Please note that this information is based on available resources and may not be fully comprehensive or up-to-date.

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