395083-14-4 | Potassium isopropenyltrifluoroborate

CAS:395083-14-4 | Potassium isopropenyltrifluoroborate ,Description

Potassium isopropenyltrifluoroborate (KIPT) is a versatile reagent used in a variety of organic synthesis reactions. It is an organoboron compound that has been used in a wide range of applications, including the synthesis of important pharmaceuticals, agrochemicals, and other organic compounds. KIPT has also been used in a variety of biochemical and physiological experiments, due to its unique reactivity and low toxicity.
 

Scientific Research Applications

Electrochemical Synthesis and Applications

Potassium isopropenyltrifluoroborate has been effectively synthesized through electrochemical methods. This synthesis process involves the reduction of aryl bromides in the presence of triisopropyl borate. This methodology is noteworthy for its simplicity, speed, and efficiency. Significantly, it has been applied in the synthesis of a fragment of combretastatin D2, a natural product with antiproliferative activity (Nascimento et al., 2014).

Cross-Coupling Reactions

Potassium isopropenyltrifluoroborate is utilized in various cross-coupling reactions. For example, it has been involved in the Suzuki-Miyaura cross-coupling reactions, a key process in organic chemistry used for creating carbon-carbon bonds. This process employs potassium isopropenyltrifluoroborate in the presence of a palladacycle as a catalyst, providing a route to synthesize complex organic molecules with significant yields and under phosphine-free conditions (Alacid & Nájera, 2008).

Applications in Gas Separation Technologies

In another intriguing application, potassium isopropenyltrifluoroborate has been used as a carrier to facilitate the transport of CO2. This has been demonstrated in studies involving polymer electrolyte membranes, where its incorporation resulted in significantly improved CO2 separation performance (Lee & Kang, 2021).

Applications in Organic Synthesis

The compound also finds applications in organic synthesis. For instance, potassium isopropenyltrifluoroborate has been used in the palladium-catalyzed cross-coupling reaction of potassium alkynyltrifluoroborates with aryl halides or triflates, providing a practical route for creating diverse organic structures with high yields (Molander et al., 2002).

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