401-55-8 | Ethyl bromofluoroacetate

CAS:401-55-8 | Ethyl bromofluoroacetate ,Description

Ethyl bromofluoroacetate (EBFA) is a synthetic compound that has been used in scientific research since the 1950s. It is a halogenated organic compound composed of an ethyl group and a bromofluoroacetate group. EBFA has a variety of applications in the laboratory, including synthesis, biochemistry, and physiology. 
 

Scientific Research Applications

Synthesis of Unsymmetrical α,α-Diarylacetates

• Application: Ethyl bromofluoroacetate is used as a precursor for synthesizing unsymmetrical α,α-diarylacetates. This involves the formation of intermediate arylglycines and a subsequent transformation into α,α-diarylacetates. This method has shown a wide scope and efficiency in diarylation reactions, proving its utility in the synthesis of complex organic compounds (Jadhav & Singh, 2016) .

N-Formylation of Amines

• Application: In copper-catalyzed N-formylation of amines, ethyl bromodifluoroacetate serves as the N-formylating reagent. This application encompasses a range of primary, secondary, cyclic arylamines, and aliphatic amines, enabling the production of N-formamides in varying yields (Li, Zhang, Chen, & Zhang, 2018).

Visible Light Mediated Organocatalytic Activation

• Application: Utilizing visible light mediated, Eosin Y catalyzed photoredox transformation, ethyl bromofluoroacetate can be activated to react with nucleophiles like indoles and anilines. This results in the efficient synthesis of bisindolyl and bisanilinoyl acetate derivatives, highlighting its role in innovative synthesis methods (Jadhav, Bakshi, & Singh, 2015).

Cross-Coupling Reactions

• Application: Ethyl bromodifluoroacetate is used in palladium-catalyzed Negishi cross-coupling reactions with aryl bromides or triflates. This method facilitates the construction of C(sp2)-CF2 bonds under mild conditions, showcasing its relevance in forming complex molecular structures (Xia et al., 2017).

Visible-Light-Mediated Fluoroalkylation

• Application: Employing a visible-light-promoted alkylation and decarboxylation sequence, ethyl bromofluoroacetate is used for the preparation of mono- and difluoromethylated phenanthridine derivatives. This method offers a practical and unified strategy for the synthesis of these compounds at room temperature (Sun & Yu, 2014).

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