402-52-8 | 4-(Trifluoromethyl)anisole

CAS:402-52-8 | 4-(Trifluoromethyl)anisole,Description

4-(Trifluoromethyl)anisole is an organic compound. This colorless liquid exhibits solubility in various organic solvents and emits a pungent odor. It serves as a valuable reagent in organic synthesis and plays a crucial role as an intermediate.

Molecular Structure Analysis

The molecular formula of 4-(Trifluoromethyl)anisole is C8H7F3O. The molecular weight is 192.14.

Chemical Reactions Analysis

4-(Trifluoromethyl)anisole can undergo metalation preferentially or exclusively at the methoxy-neighboring position. More detailed information about its chemical reactions was not found in the search results.

Physical And Chemical Properties Analysis

4-(Trifluoromethyl)anisole has a refractive index n20/D of 1.432 (lit.), a boiling point of 164 °C (lit.), and a density of 1.266 g/mL at 25 °C (lit.). It also has a flash point of 59.2±21.8 °C.

Scientific Research Applications

Trifluoromethyl ethers are finding increased utility as a substituent in bioactives, but they are still perhaps the least well understood fluorine substituent in currency. They are synthesized in pharmaceutical research on a routine basis and about 10% of all marketed pharmaceuticals contain a fluorine atom. There has been an enormous increase in the use of fluorine containing compounds for medicinal applications.

• Electrophilic Aromatic Substitution of Substituted Benzenes : This is a common reaction in organic chemistry where an electrophile substitutes a hydrogen atom in an aromatic system. “4-(Trifluoromethyl)anisole” is a type of substituted benzene, and its high reactivity requires that reactions be conducted under very mild conditions. The specific application of this compound in such reactions would depend on the nature of the research.
• Synthesis and Properties of Trifluoromethyl Ethers : Trifluoromethyl ethers, including “4-(Trifluoromethyl)anisole”, are finding increased utility as a substituent in bioactives. They are synthesized in pharmaceutical research on a routine basis and about 10% of all marketed pharmaceuticals contain a fluorine atom. There has been an enormous increase in the use of fluorine containing compounds for medicinal applications.
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Safety And Hazards

4-(Trifluoromethyl)anisole is a flammable liquid and vapor. It causes skin irritation, serious eye irritation, and may cause respiratory irritation.

Relevant Papers The paper “Trifluoromethyl ethers – synthesis and properties of an unusual substituent” discusses the synthesis and properties of trifluoromethyl ethers, a group that includes 4-(Trifluoromethyl)anisole. The paper provides an overview of the synthesis, properties, and reactivity of this important substituent.

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