406-91-7 | 4,4,4-Trifluorobutanoyl chloride

CAS:406-91-7 | 4,4,4-Trifluorobutanoyl chloride ,Description

4,4,4-Trifluorobutanoyl chloride (TFBC) is a fluorinated organic compound that is widely used as a reagent in organic synthesis. It is a colorless liquid with a pungent odor and is highly reactive. It is used in a variety of applications such as the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. TFBC is also used in the production of fluorinated polymers and in the manufacture of fluorinated surfactants.
 

Scientific Research Applications

Quantum Yield Studies in Gas Phase

A study investigated the photolysis of 4-chloroperfluorobutanoyl chloride vapour, demonstrating its utility as a gas phase actinometer due to its stable quantum yields under various conditions (Weibel, Staricco, & Starrico, 1990).

Electrochemical Fluorination

Electrochemical fluorination of 4-(perfluoro-n-butyl)-n-butanoyl chloride leads to the production of perfluorooctanoyl fluoride, demonstrating an application in fluorine chemistry and material processing (Napoli, Conte, Gambaretto, & Carlini, 1989).

Nanoparticle Synthesis

The compound was used in the electrochemical synthesis of nanoparticles, indicating its role in nanotechnology and material science (Goodarzi & Mirza, 2020).

Yeast Reduction and Chirality Determination

Research on the yeast reduction of ethyl 4,4,4-trichloro- and 4,4,4-trifluoro-3-oxobutanoate, related to the compound of interest, has provided insights into the production of high-purity enantiomers, crucial in pharmaceutical research and chiral chemistry (Seebach, Renaud, Schweizer, Züger, & Brienne, 1984).

Catalysis in Alkylation Reactions

Trifluoroethanol, related to trifluorobutanoyl chloride, has been studied for its role in the catalysis of alkylation reactions, demonstrating the importance of fluorinated compounds in enhancing chemical reactions (Ren, Zhao, Zhang, Cui, & Huang, 2012).

Pharmaceutical and Agrochemical Synthesis

Trifluoromethyl groups, closely related to trifluorobutanoyl chloride, play a crucial role in pharmaceutical and agrochemical compound design due to their electron-withdrawing properties and ability to influence molecular properties (Cho et al., 2010).

Influence in Crystal Packing

Studies on fluorinated derivatives, including those related to 4,4,4-trifluorobutanoyl chloride, have shown their impact on crystal packing in Co(II) complexes, indicating their potential in material science and coordination chemistry (Perdih, 2014).

Polymer Material Development

Research into the synthesis of novel fluorinated acrylate polymers, including derivatives of perfluorobutanoyl chloride, highlights its role in developing advanced materials with unique properties (Zhang, Wang, Zhan, & Chen, 2014).

Membrane Science

The compound's derivatives have been used in the synthesis of novel monomers for thin film composite membranes, which are essential in the field of membrane science for applications like reverse osmosis and water purification (Li, Zhang, Zhang, & Zheng, 2007).

Studying Thiol Reactivity

Research on the reaction of 4,4,4-trifluorobutanethiol on metal surfaces has provided insights into the reactivity of thiols influenced by fluorination, relevant in surface chemistry and material science (Napier & Friend, 1996).

Improvements in Electrochemical Processes

Studies on the electrochemical fluorination of octanoyl chloride to produce perfluorinated compounds reveal advancements in chemical processing and fluorine chemistry (Prokop et al., 1989).

Radical Copolymerization Studies

Investigations into the radical copolymerization of 2-trifluoromethylacrylates, closely related to 4,4,4-trifluorobutanoyl chloride, offer insights into polymer chemistry and material design (Ito, Trinque, Kasai, & Willson, 2008).

More Information