407-38-5 | 2,2,2-Trifluoroethyl trifluoroacetate

CAS:407-38-5 | 2,2,2-Trifluoroethyl trifluoroacetate ,Description

2,2,2-Trifluoroethyl trifluoroacetate (TFTA) is a colorless, volatile liquid that is used in a variety of scientific research and industrial applications. It is a synthetic compound with a molecular formula C4H3F5O2, and is a member of the trifluoroacetate family of compounds. TFTA is a versatile compound that has a wide range of applications in the laboratory, including use as a solvent, a reagent, and a catalyst. 
 

Scientific Research Applications

• Radiochemistry and Medicinal Applications:
  • Used in the synthesis of [18F]-labelled alkylating agents, specifically for 2,2,2-trifluoroethyl triflate. This compound has been applied in radiolabelling 2-oxoquazepam, a method valuable in positron emission tomography (PET) imaging studies (Johnström & Stone-Elander, 1995) .
• Organic Synthesis:
  • In electrochemical trifluoromethylation, it's used to create complex molecules like 2,3-bis(2,2,2-trifluoroethyl)succinonitrile and 3,4- dicyano-2,5-bis(trifluoromethyl)-n-hexane, highlighting its versatility in synthesizing fluorinated organic compounds (Dmowski et al., 1997).
  • Also plays a role in the creation of fluorinated organics in the environment, which are significant due to their unique properties and widespread use (Key, Howell, & Criddle, 1997).
• Photocatalysis and Material Science:
  • Its derivatives, like trifluoroacetic acid, are used in modifying the properties of photocatalysts like F-doped TiO2, enhancing their efficiency in photocatalysis applications (Samsudin et al., 2016).
• Catalysis and Chemical Transformations:
  • Acts as a starting material or intermediate in various catalytic processes, like the solvolytic and nonsolvolytic nucleophilic ring opening of epoxides (Iranpoor & Adibi, 2000).
• Spectroscopy and Structural Analysis:
  • Used in studies involving the molecular structure and vibrational properties of fluorinated compounds, contributing to a deeper understanding of their physical and chemical characteristics (Lestard et al., 2009).
• Metabolism and Toxicology:
  • Investigated for its metabolism and potential toxicity in animal models, which is important for understanding the environmental and health impacts of fluorinated compounds (Selinsky et al., 1991).

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