4084-38-2 | 2,3,5,6-Tetrafluorobenzyl alcohol

CAS:4084-38-2 | 2,3,5,6-Tetrafluorobenzyl alcohol ,Description

2,3,5,6-Tetrafluorobenzyl alcohol (TFBA) is a highly fluorinated alcohol that has been used in a variety of scientific research applications. It is a colorless, volatile liquid with a boiling point of 77°C and a melting point of -41°C. TFBA is a versatile compound with a wide range of applications in organic synthesis, catalysis, and materials science. It is also used as a reagent in various biochemical and physiological studies. 
 

Scientific Research Applications

Electrochemical Synthesis

Product-Selective Electroreduction: 2,3,5,6-Tetrafluorobenzyl alcohol can be selectively synthesized through the electrochemical reduction of 2,3,4,5,6-pentafluorobenzoic acid. This process involves the use of solid cathodes in aqueous sulfuric acid solutions, demonstrating the compound's application in electrochemical synthesis (Iwasaki et al., 1987); (Sato et al., 1992).

Pyrethroid Research and Development

Fluorinated Pyrethroids: This compound has played a significant role in the development of fluorinated pyrethroids, leading to increased efficacy of certain insecticides. It is especially notable in the commercialization of broad-spectrum insecticides such as cyfluthrin and others (Naumann, 1998).

Analytical Chemistry

Urinary Metabolites Analysis: In the field of analytical chemistry, 2,3,5,6-Tetrafluorobenzyl alcohol is used as a biomarker for monitoring exposure to certain pyrethroids. Its presence in urinary metabolites aids in assessing exposure to these compounds (Yoshida, 2013); (Yoshida, 2015).

Polymer Chemistry

Polymer Modification: It has applications in polymer chemistry, where it's used for postpolymerization modification. For instance, the para-fluoride in poly(2,3,4,5,6-pentafluorobenzyl methacrylate) can be substituted with sodium azide, showing its utility in creating versatile polymers (Noy et al., 2019) .

Environmental and Health Monitoring

Temporal Trends in Exposure: Studies have used this compound to monitor temporal trends and seasonal differences in exposure to hygiene-used pyrethroids in Japanese children, demonstrating its relevance in environmental health research (Hamada et al., 2020).

Chemical Synthesis

Intermediate in Synthesis: 2,3,5,6-Tetrafluorobenzyl alcohol acts as an intermediate in the synthesis of various compounds, including tefluthrin, a potent insecticide (Wu Xiao-yan, 2006).

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