421-53-4 | Trifluoroacetaldehyde hydrate

CAS:421-53-4 | Trifluoroacetaldehyde hydrate ,Description

Trifluoroacetaldehyde hydrate (TFAH) is a chemical compound composed of trifluoroacetaldehyde, a colorless liquid, and water. It is a colorless, volatile liquid with a pungent odor and is miscible with organic solvents. TFAH is used in a wide range of applications in both organic and inorganic chemistry, including synthesis, purification, and catalysis. It is also used in biochemistry, as an intermediate in the synthesis of various compounds, and in the production of pharmaceuticals.
 

Scientific Research Applications

Trifluoroacetaldehyde as a Trifluoromethyl Source

Trifluoroacetaldehyde hydrate serves as an atom-economical trifluoromethyl source for the nucleophilic trifluoromethylation of carbonyl compounds. This method is broadly applicable and offers satisfactory yields, contributing significantly to the development of compounds with trifluoromethyl groups (Prakash et al., 2013).

Precursor for Trifluoroacetaldehyde and Its Derivatives

Trifluoroacetaldehyde hydrate is used as a precursor for various synthetic applications, including the preparation of trifluoroacetaldehyde and its derivatives. It is effective in producing substances like trifluoroacetaldehyde O-(aryl)oxime, crucial for the synthesis of trifluoromethylated oxadiazoles (Lin et al., 2022).

Synthesis of Beta-Hydroxy-Beta-Trifluoromethyl Ketones

A key application of trifluoroacetaldehyde hydrate is in the synthesis of beta-hydroxy-beta-trifluoromethyl ketones from enamines and imines. This process is highly efficient, yielding a wide range of such ketones with good to excellent yields (Funabiki et al., 2003).

Mannich Reaction for Heterocycle Synthesis

Trifluoroacetaldehyde hydrate is used in the Mannich reaction with NH-aryl hydrazones. This reaction is instrumental in creating trifluoromethyl-substituted heterocycles, which have various applications in chemical synthesis (Jia & El Kaim, 2018).

Preparation of Trifluoroethylamino Derivatives

In industrial chemistry, trifluoroacetaldehyde is utilized for synthesizing trifluoromethylated amino compounds. This includes the formation of trifluoroethylamino derivatives through reductive amination, producing these compounds in moderate to good yields (Mimura et al., 2010).

Synthesis of Trifluoromethyl Nitrones

Trifluoroacetaldehyde hydrate is also used to synthesize trifluoromethyl nitrones. These nitrones can undergo nucleophilic diastereoselective additions to form optically active trifluoroethyl hydroxylamines (Milcent et al., 2010).

Defluorinative Alkylation

Trifluoroacetaldehyde hydrate derivatives are involved in defluorinative alkylation. This process is important for creating various compounds by eliminating fluorine atoms and introducing alkyl groups (Yanai & Taguchi, 2009).

Synthesis of Trifluoroethyl-Containing Substances

Trifluoroacetaldehyde N-tosylhydrazone, derived from trifluoroacetaldehyde hydrate, is used as a precursor for trifluorodiazoethane in various synthesis reactions. This precursor is essential for creating trifluoroethyl-containing substances (Ostrovskii et al., 2019).

Catalytic Oxidation Studies

Trifluoroacetaldehyde hydrate is synthesized through catalytic oxidation processes, which are important in industrial chemistry. These studies focus on optimizing conditions for producing trifluoroacetaldehyde efficiently (Chunyan, 2007).

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