423-50-7 | Perfluorohexanesulphonyl fluoride

CAS:423-50-7 | Perfluorohexanesulphonyl fluoride ,Description

Perfluorohexanesulphonyl fluoride (PFHxS) is a fluorinated organic compound that has been used in a variety of industrial and laboratory applications. PFHxS is a highly fluorinated compound with a carbon-fluorine bond, making it a very stable compound. It is used in a variety of industries, from pharmaceuticals to electronics and from food processing to aerospace. PFHxS has also been used in scientific research for a variety of purposes, including as a reagent for organic synthesis, as a catalyst for reactions, and as a substrate for enzymatic reactions. 
 

Scientific Research Applications

Analytical Method Development

• A novel liquid chromatography–fluorescence method was developed for determining perfluorooctanesulphonyl fluoride (PFOSF), a precursor of PFOS ubiquitous in the environment. This method involves derivatising PFOSF with 1-naphthol for effective analysis using liquid chromatography with UV and fluorescence detection (Meng et al., 2014) .

Fluoride Ion Sensing and Complexation

• Research into fluoride ion complexation and sensing using organoboron compounds has been significant due to fluoride's health benefits and potential hazards. This research is vital for detecting fluoride in water and other substances (Wade et al., 2010).

Environmental Impact Studies

• A study on artificial turfs in Stockholm, Sweden, showed widespread occurrence of non-extractable fluorine, indicative of polymeric organofluorine presence. This research highlights the environmental footprint of fluorinated substances in commercial products (Lauria et al., 2022).

Energy Storage and Conversion

• Iron(III) fluorides, related to fluorides like perfluorohexanesulphonyl fluoride, have garnered interest in energy storage and conversion, particularly in Li-ion technology, due to their potential for enhanced energy storage (Conte & Pinna, 2014).

Water Treatment and Pollution Control

• Photo-reductive defluorination of perfluorooctanoic acid in water has been studied, highlighting methods for treating pollution from fluorinated compounds in aquatic environments (Qu et al., 2010).
• Emission inventories for various perfluoroalkyl carboxylic acids (PFCAs) from different sources, including products based on perfluorohexane sulfonyl fluoride, have been investigated, providing insights into the environmental impact of these substances (Wang et al., 2014).

Organic Synthesis and Fluorination Techniques

• Advances in electrochemical systems for selective fluorination of organic compounds have been explored, which is crucial in creating organofluorine compounds used in pharmaceuticals and agrochemicals (Fuchigami & Inagi, 2020).
• Large-scale sonochemical reactors have been used for treating perfluorooctane sulfonic acid, demonstrating an efficient method for dealing with persistent fluorinated pollutants (Gole et al., 2018).

Novel Fluorinated Compounds Synthesis

• Research on synthesizing potentially non-bioaccumulable fluorinated surfactants addresses concerns about the toxicity and persistence of fluorinated products, providing alternative pathways for safer fluorosurfactants production (Zaggia & Améduri, 2012).

Fluorine in Pharmaceuticals and Imaging

• Spirocyclic hypervalent iodine(III)-mediated radiofluorination has been developed for non-activated aromatics, crucial for producing radiopharmaceuticals for PET imaging (Rotstein et al., 2014).

Human Biomonitoring Studies

• A pilot survey of legacy and current commercial fluorinated chemicals in human sera from US donors in 2009, including analysis of perfluorooctanesulfonyl fluoride (POSF) derivatives, provides data on human exposure to these compounds (Lee & Mabury, 2011).

Plasma-based Water Treatment Process

• Breakdown products from perfluorinated alkyl substances (PFAS) degradation in plasma-based water treatment processes have been quantified, contributing to understanding the environmental impact of decomposing PFAS (Singh et al., 2019).

Genetic Engineering for Fluorination

• A fluoride-responsive genetic circuit enabling in vivo biofluorination in engineered Pseudomonas putida has been developed, demonstrating new methods for biosynthesizing fluorinated compounds (Calero et al., 2020).

Fluorine in Waste Incineration

• Investigation of waste incineration of fluorotelomer-based polymers provides insights into whether this process contributes to environmental PFOA exposure (Taylor et al., 2014).

Tissue Distribution Studies

• Tissue distribution of 35S-labelled perfluorobutanesulfonic acid in mice following dietary exposure, related to the study of perfluorohexanesulphonyl fluoride, shows how these compounds distribute in biological systems (Bogdanska et al., 2014).

Fluoride Ion Channels and Sensors

• Development of a fluoride-driven ionic gate based on 4-aminophenylboronic acid-functionalized single nanochannels opens new possibilities for fluoride sensing and regulation (Liu et al., 2014).

Plasma Treatment for PFOS Decomposition

• An energy-efficient process for decomposing PFOA and PFOS using dc plasmas generated within gas bubbles highlights advancements in treating these persistent substances (Yasuoka et al., 2011).

Blood Donor Biomonitoring for Fluorinated Compounds

• A study on ADONA and perfluoroalkylated substances in plasma samples of German blood donors living in South Germany provides insights into the body burden of different perfluorinated substances in human populations. This research is significant for understanding human exposure to compounds like perfluorohexanesulphonyl fluoride (Fromme et al., 2017).

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