423-55-2 | Perflubron

CAS:423-55-2 | Perflubron ,Description

Perflubron (also known as perfluorooctyl bromide or PFOB) is a synthetic liquid perfluorocarbon (PFC) which has a range of potential applications in the medical, biological, and physical sciences. Perflubron has a wide range of properties which have made it attractive for use in a variety of scientific research applications. It is non-flammable, non-toxic, non-corrosive, and has a low vapor pressure. It is also a powerful oxygen carrier, which makes it ideal for use in many in vivo and in vitro experiments.
 

Scientific Research Applications

Oxidative Damage Attenuation

Perflubron demonstrates a capability to protect against oxidative damage in both biological and nonbiological systems. This property is independent of its anti-inflammatory properties. In studies, perflubron showed a significant reduction in oxidative stress in cell cultures and lessened oxidative damage to linoleic acid, indicating its potential in mitigating oxidative injury (Rotta et al., 2003).

Ultrasound and CT Imaging Enhancement

Perflubron is effective as an ultrasound and computed tomography (CT) contrast agent. It enhances the echogenicity of flowing blood, improving visibility in imaging studies. This property is valuable in medical diagnostics, particularly in imaging vascular structures (André et al., 1993) .

MR Imaging for Crohn's Disease

In the field of magnetic resonance (MR) imaging, particularly for patients with Crohn's disease, perflubron serves as an effective oral contrast agent. It has been shown to improve the clarity of bowel wall visualization, aiding in the assessment of gastrointestinal conditions (Anderson et al., 1994).

Vitreoretinal Surgery Applications

Perflubron is used in vitreoretinal surgery as a vitreous substitute. Studies indicate its safety for intraocular use, both intraoperatively and for longer terms. Its properties allow for efficient manipulation during vitreoretinal procedures, showing potential in ophthalmological surgeries (Flores-Aguilar et al., 1995).

CT Angiography

In CT angiography, perflubron has been used as a blood pool contrast agent. It enables the visualization of vascular structures, which is crucial for diagnosing and planning treatment for vascular diseases. This application shows its versatility in enhancing imaging capabilities for medical diagnostics (Fruman et al., 1994).

Liquid Ventilation

Perflubron is significant in liquid ventilation applications, particularly for treating respiratory distress syndromes. It improves gas exchange and lung compliance in various models of respiratory failure, indicating its potential as a therapeutic tool in critical care settings (Day & Gedeit, 1998).

Gene Therapy

In gene therapy research, particularly for lung diseases, perflubron enhances gene expression when used in conjunction with intratracheal administration of vectors. This application opens new possibilities in the field of molecular therapy and gene delivery systems (Weiss et al., 2002).

Lymph Node Imaging

Perflubron emulsion has been developed to enhance lymph nodes on CT images. This application is particularly useful in oncology for detecting lymph node metastases and for surgical planning (Hanna et al., 1994).

Anti-Inflammatory Effects in Respiratory Conditions

Perflubron shows anti-inflammatory effects in the alveolar environment, reducing the inflammatory response in trauma patients with respiratory distress. This property is crucial for managing patients in critical care and for understanding the pathophysiology of respiratory diseases (Croce et al., 1997).

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