425-61-6 | 2,2,3,3-Tetrafluoro-1,4-butanediol

CAS:425-61-6 | 2,2,3,3-Tetrafluoro-1,4-butanediol ,Description

2,2,3,3-Tetrafluoro-1,4-butanediol (TFB) is a versatile compound that has been used in a variety of industrial, commercial, and research applications. It is a colorless, odorless, and non-toxic liquid with a boiling point of 77.3 °C and a melting point of -53.9 °C. TFB has a low vapor pressure and is miscible in water and organic solvents, making it an ideal solvent for many applications. It is also a versatile reagent for organic synthesis, due to its low toxicity and low reactivity.
 

Scientific Research Applications

Antiviral Evaluation

One significant application of 2,2,3,3-tetrafluoro-1,4-butanediol is in the synthesis of fluorinated acyclic nucleosides and their phosphoramidates. Mahmoud et al. (2017) explored this compound's use in creating antiviral agents effective against HIV, HCV, HSV-1, and HBV, along with assessing cytotoxicity in various cell lines (Mahmoud et al., 2017).

Catalyst in Chemical Synthesis

Another application is in the catalytic dehydration of 1,4-butanediol to produce important chemicals like 3-buten-1-ol and tetrahydrofuran (THF). Yamamoto et al. (2005) and Igarashi et al. (2007) have shown that using specific catalysts like ZrO2 and lanthanide oxides can efficiently drive these reactions, yielding products with potential industrial applications (Yamamoto et al., 2005); (Igarashi et al., 2007).

Microbial Production

The microbial production of 2,3-butanediol, a derivative of 1,4-butanediol, is another area of research. Ji et al. (2011) and Kim et al. (2015) discuss the optimization of microbial strains and bioprocesses for efficient and economical production, highlighting the industrial relevance of these compounds (Ji et al., 2011); (Kim et al., 2015).

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