425-88-7 | 1,1,2,2-Tetrafluoro-1-methoxyethane

CAS:425-88-7 | 1,1,2,2-Tetrafluoro-1-methoxyethane ,Description

1,1,2,2-Tetrafluoro-1-methoxyethane (TFMME) is a fluorinated hydrocarbon which has a wide range of industrial and laboratory applications. It is a colourless liquid with a boiling point of 10.1°C and a melting point of -58.7°C. It is miscible with water and is used as a solvent in a variety of applications. TFMME is also known as 1,1,2,2-tetrafluoroethanol, 1,1,2,2-tetrafluoropropanol, and 1,1,2,2-tetrafluoropropane.
 

Scientific Research Applications

Fluorination of Chlorofluoroether

Sekiya et al. (2001) investigated the reaction of 1,2-dichloro-1,1,2-trifluoro-2-methoxyethane with anhydrous hydrogen fluoride in the presence of metal fluorides supported on porous aluminum fluoride. This reaction led to the formation of 2-chloro-1,1,2,2-tetrafluoro-2-methoxyethane, a new compound, demonstrating its potential in the fluorination of chlorofluoroether (Sekiya et al., 2001).

Lithium-ion Batteries

Liu et al. (2016) introduced a new mixture of 3-(2-methoxyethoxy)propanenitrile, fluoroethylene carbonate, and 1,1,2,2-tetrafluoroethyl-2,2,3,3-tetrafluoropropyl ether as safe electrolytes for lithium-ion batteries. This electrolyte combination demonstrated high safety and better wettability to separator and electrodes than conventional electrolytes, indicating the potential use of 1,1,2,2-tetrafluoro-1-methoxyethane in battery technologies (Liu et al., 2016).

Direct Introduction of the CF2Me Moiety

Carbonnel et al. (2019) discussed the importance of fluorine-containing molecules in various industries, including the use of the CF2Me residue as a bioisostere of the methoxy group. The research highlighted the quest for methodologies for the direct 1,1-difluoroethylation of molecules, which could potentially involve compounds like 1,1,2,2-tetrafluoro-1-methoxyethane (Carbonnel et al., 2019).

Rotational Isomerism Studies

Cavalli and Abraham (1970) analyzed the 1H and 19F spectra of 1,1,2,2-tetrafluoroethane, which is closely related to 1,1,2,2-tetrafluoro-1-methoxyethane, to understand its rotational isomerism. This research provides insight into the physical properties and behavior of similar fluorinated compounds (Cavalli & Abraham, 1970).

Electrochemical Properties in Batteries

Schmitz et al. (2012) evaluated Methyl tetrafluoro-2-(methoxy) propionate (MTFMP), closely related to 1,1,2,2-tetrafluoro-1-methoxyethane, as a co-solvent for propylene carbonate-based electrolytes in lithium-ion batteries. Their research indicated the potential of such compounds in improving battery performance (Schmitz et al., 2012).

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