430-67-1 | 2,2-Difluoroethylamine

CAS:430-67-1 | 2,2-Difluoroethylamine ,Description

2,2-Difluoroethylamine, also known as 2,2-difluoroethanamine or DFEA, is an organic compound with the chemical formula C2H4F2N. It is a colorless liquid with a pungent odor and is classified as a volatile organic compound (VOC). It is a highly reactive compound and is used in a variety of industrial and scientific applications. It is also used in the synthesis of pharmaceuticals and other organic compounds.
 

Scientific Research Applications

Perovskite Solar Cells

• Defect Passivation: 2,2-Difluoroethylamine (2FEA) is used to passivate defects in perovskite solar cells. It has been found to improve device performance and stability significantly, leading to efficiencies up to 23.4% and enhanced environmental stability. This is attributed to the distribution of fluorine atoms throughout the perovskite film, which suppresses nonradiative recombination and improves carrier lifetime【Su et al., 2021】(Su et al., 2021).

Medical Applications

• Blood Substitutes: 2,2-Difluoroethylamine derivatives, particularly in the form of perfluorocarbons like Fluosol-DA, have been used in clinical studies as blood substitutes. These compounds have shown promise in delivering oxygen and extending plasma, without significant adverse reactions in most cases【Mitsuno et al., 1982】(Mitsuno et al., 1982).

Organic Synthesis

• Selective Difluoromethylation: 2,2-Difluoroethylamine and its related compounds are integral in selective difluoromethylation reactions, crucial for creating fluorine-containing pharmaceuticals and agrochemicals. These reactions are essential for introducing difluoromethyl and monofluoromethyl groups into organic molecules, offering a straightforward method for synthesizing various important compounds【Hu et al., 2009】(Hu et al., 2009).

Tumor Imaging

• Ultrasound Contrast Agents: Perfluorocarbons, including derivatives of 2,2-Difluoroethylamine, have been tested as ultrasound contrast agents for tumor imaging and hepatosplenography. These compounds have shown potential in enhancing the visualization of liver metastases and other lesions in clinical studies【Mattrey et al., 1987】(Mattrey et al., 1987).

Pharmaceuticals

• Bioactive Heterocycles Synthesis: 2,2-Difluoroethylamine plays a role in synthesizing heterocycles containing difluoromethyl groups. These heterocycles are emerging as important organofluoro molecules in pharmaceutical, agricultural,and material science applications. A study demonstrated an organophotocatalytic direct difluoromethylation of heterocycles using O2 as a green oxidant, enriching the synthesis of difluoromethylated heterocycles for potential drug development【Zhang et al., 2020】(Zhang et al., 2020).

Synthesis of Fluorinated Analogs

• Fluorinated Analogs of Neurotransmitters: Synthesizing 2,2-difluoro-2-arylethylamines as fluorinated analogs of octopamine and noradrenaline has been explored. These syntheses aim to create bioisosteric OH/F exchanges, providing a pathway to novel compounds with potentially unique biological activities【Tarui et al., 2022】(Tarui et al., 2022).

Environmental and Occupational Health

• Worker Serum Concentration Assessment: Epidemiologic assessment of worker serum concentrations of perfluorooctanesulfonate and perfluorooctanoate, related to 2,2-Difluoroethylamine, has been conducted. This study helps understand the environmental and occupational exposure to such compounds, contributing to safety and health guidelines【Olsen et al., 2003】(Olsen et al., 2003).

Catalysis and Organic Reactions

• Amination of 1-Halo-2,2-Difluoroethane: Research on the preparation of 2,2-difluoroethylamine through the amination of 1-halo-2,2-difluoroethane has been conducted, providing insights into the synthetic routes and reaction mechanisms for producing this compound【Han et al., 2020】(Han et al., 2020).

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