430-99-9 | 2-Fluoroacrylic acid

CAS:430-99-9 | 2-Fluoroacrylic acid ,Description

2-Fluoroacrylic acid, also known as 2-fluoropropionic acid, is a carboxylic acid that is widely used in the field of organic chemistry. It is a colorless, volatile liquid with a pungent odor. It has a melting point of -50°C and a boiling point of 108°C. It is soluble in water, alcohol, and ether, and is highly reactive with strong oxidizing agents. 2-Fluoroacrylic acid is used in the synthesis of various compounds, including pharmaceuticals, polymers, and surfactants. It can also be used in the production of dyes, resins, and other organic compounds. 
 

Scientific Research Applications

Synthesis and Characterization

2-Fluoroacrylic acid is a key intermediate in the synthesis of various compounds, offering unique properties due to the presence of the fluoro group. For example, its derivatives are crucial in the manufacture of pharmaceuticals like flurbiprofen, highlighting the importance of developing efficient synthesis methods. One study details a practical approach to synthesizing 2-Fluoro-4-bromobiphenyl, a crucial step in flurbiprofen production, emphasizing the significance of finding cost-effective and environmentally friendly synthesis routes for such intermediates (Qiu et al., 2009).

Environmental and Biodegradation Studies

The environmental impact and degradation pathways of fluorinated compounds, including those related to 2-fluoroacrylic acid, are crucial areas of research. Studies on polyfluoroalkyl chemicals provide insights into the environmental fate, biodegradability, and potential health risks of these substances. For instance, research into the microbial degradation of polyfluoroalkyl chemicals in the environment reveals the complexity of biodegradation pathways and the persistence of these compounds, underscoring the need for further investigation into their environmental impact and degradation mechanisms (Liu & Avendaño, 2013).

Applications in Biomaterials and Biomedical Engineering

2-Fluoroacrylic acid and its polymers have promising applications in the biomedical field, particularly in tissue engineering and drug delivery systems. The surface functionalization and patterning techniques using acrylic acid derivatives facilitate the design of interfaces for biomedical applications, including enhancing cell adhesion and proliferation. Such functionalized surfaces are critical for developing advanced biomaterials for various medical applications, ranging from wound healing to the construction of artificial organs (Brétagnol et al., 2006) .

Advanced Materials and Green Chemistry

The exploration of fluorinated materials in green chemistry and advanced material applications is another significant area of research. Studies focus on the synthesis, properties, and applications of carbon solid acids, including those derived from or related to 2-fluoroacrylic acid. These materials are essential for renewable energy, environmental remediation, and as catalysts in various chemical reactions, emphasizing the role of fluorinated compounds in developing sustainable technologies and materials (Mahajan & Gupta, 2019).

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