431-05-0 | 1,1-Difluoroacetone

CAS:431-05-0 | 1,1-Difluoroacetone ,Description

1,1-Difluoroacetone (DFA) is a versatile and useful molecule that has a wide range of applications in scientific research and the laboratory. It is a colorless, odorless, and volatile liquid with a boiling point of 61.3 °C and a melting point of -41.2 °C. DFA is used in a variety of laboratory experiments, including organic synthesis, chromatography, and mass spectrometry. It is also used to study the biochemical and physiological effects of various compounds and drugs.
 

Scientific Research Applications

Metabolism and Toxicology

The metabolism of difluoroacetone derivatives in living organisms and their toxicological impacts have been studied. For instance, 1,3-difluoroacetone, a metabolite of a pesticide component, was investigated for its toxic action via conversion to toxic compounds in rat kidneys. This research offers insights into the biochemical pathways and potential risks associated with difluoroacetone compounds, highlighting their relevance in toxicology and environmental health studies (Menon et al., 2001).

Structural Analysis

The structural determination of difluoroacetone compounds, such as the carbon-13 backbone structure of 1,3-difluoroacetone, underscores the importance of these compounds in molecular chemistry and materials science. Understanding their structure is crucial for the development of new materials and chemical synthesis processes (Grubbs, 2017).

Synthesis and Chemical Reactions

Various synthetic methods and chemical reactions involving difluoroacetone derivatives highlight the compound's versatility in organic synthesis. For example, the synthesis of 2,2-Difluoroethanol from difluoroacetic acid or acetate illustrates the reactivity and application of difluoro compounds in producing industrially relevant chemicals (Yan Zong-gang, 2010).

Catalysis and Photoredox Reactions

Difluoroacetone derivatives are utilized in catalysis and photoredox reactions, indicating their potential in green chemistry and sustainable processes. For instance, visible-light-triggered direct keto-difluoroacetylation of styrenes showcases the application of difluoroacetone derivatives in synthesizing functionalized ketones, which are valuable in pharmaceuticals and agrochemicals (Luo et al., 2019).

Applications in Material Science

The integration of difluoroacetone derivatives into materials science is exemplified by the synthesis of graphene oxide/rare-earth complex hybrid luminescent materials. This application demonstrates the role of difluoro compounds in enhancing the functional properties of materials for use in electronics, optics, and biotechnology (Zhao et al., 2016).

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