431-39-0 | 3,3,3-Trifluoropropane-1,2-diol

CAS:431-39-0 | 3,3,3-Trifluoropropane-1,2-diol ,Description

3,3,3-Trifluoropropane-1,2-diol (TFP) is a multifunctional diol with a wide variety of applications in chemical and biological research. TFP has been used as a reagent in the synthesis of organic molecules, as a solvent to facilitate reactions, and as a stabilizing agent in biochemistry. Its unique properties make it an ideal compound for use in laboratory experiments. 
 

Scientific Research Applications

Chiral Analysis Applications

• Chiral Tagging for Spectroscopic Analysis: 3,3,3-Trifluoropropane-1,2-diol and its homologs have shown promise in chiral analysis. Their simple rotational spectra enable the conversion of enantiomers into spectroscopically distinct diastereomers through the formation of non-covalently bound complexes, aiding in chiral analysis (Leung et al., 2020).

Synthetic Chemistry

• Synthesis of Trifluoromethyl-Substituted Compounds: Trifluoromethyl-containing compounds have diverse applications in pharmaceuticals and agrochemicals. The synthesis of 3,3,3-trifluoropropynyl-substituted compounds provides versatile building blocks for target molecules containing trifluoromethyl groups. This makes 3,3,3-Trifluoropropane-1,2-diol a critical component in advanced medicinal chemistry (Shimizu et al., 2009).

Biotransformation Studies

• Studying Biotransformation in Animals: Investigations into the biotransformation of related compounds like 2,3,3,3-tetrafluoropropene in rabbits have been conducted to understand metabolic processes. These studies are crucial for understanding how similar compounds, including 3,3,3-Trifluoropropane-1,2-diol, are metabolized in biological systems (Schuster et al., 2010).

Industrial Applications

• Industrial Synthesis of Fluorinated Compounds: 3,3,3-Trifluoropropane-1,2-diol serves as a starting point for the synthesis of various fluorinated compounds. These compounds have significant industrial applications, including in the production of polymers and refrigerants (Cheng et al., 2020).

Analytical Chemistry

• Sensor Development for Food Contaminants: Research involving analogs of 3,3,3-Trifluoropropane-1,2-diol, such as 3-monochloropropane-1,2-diol, has led to the development of sensors for detecting food contaminants. These developments are critical in ensuring food safety and public health (Fang et al., 2019).

Pharmaceutical Research

• Advanced Drug Synthesis: The compound is used in the synthesis of trifluoromethyl ketones, which are potent inhibitors of various enzymes. This application is particularly relevant in pharmaceutical research for developing new therapeutic agents (Rayo et al., 2010).

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