433-97-6 | 2-(Trifluoromethyl)benzoic acid

CAS:433-97-6 | 2-(Trifluoromethyl)benzoic acid,Description

2-(Trifluoromethyl)benzoic Acid is used in biochemical genetics studies such as Plasmid-encoded phthalate catabolic pathway in Arthrobacter keyseri 12B. It is a benzoic acid carrying a trifluoromethyl substituent at the 2-position.

Synthesis Analysis

2-(Trifluoromethyl)benzoic acid was used in the synthesis of 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety. It was also used to investigate the binding of 2-pyridinone and amino acid derivative as ligands with chaperones PapD and FimC by surface plasmon resonance and 1 HNMR spectroscopy.

Molecular Structure Analysis

The molecular structure of 2-(Trifluoromethyl)benzoic acid is available as a 2d Mol file or as a computed 3d SD file.

Chemical Reactions Analysis

2-(Trifluoromethyl)benzoic acid is a benzoic acid carrying a trifluoromethyl substituent at the 2-position. It was used in the synthesis of 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety.

Physical And Chemical Properties Analysis

2-(Trifluoromethyl)benzoic acid is a slightly yellow to yellow-brown crystalline powder. More detailed physical and chemical properties such as density, melting point, boiling point, and molecular weight can be found in various databases.

Scientific Research Applications

Catalytic Applications

Wang et al. (2017) describe a catalyst-free method for the decarboxylative trifluoromethylation/perfluoroalkylation of benzoic acid derivatives. This environmentally friendly transformation is performed in water-acetonitrile and is scalable with good yield (Wang et al., 2017).

Pharmaceutical Research

Liu et al. (2021) achieved trifluoromethylation of benzoic acids with TMSCF3 using anhydrides as an in situ activating reagent. This method provides a facile way to prepare aryl trifluoromethyl ketones, potentially useful in pharmaceutical applications (Liu et al., 2021).

Material Science

Pei et al. (2020) discuss the preparation of polyaniline/Al bismuthate composite nanorods for effective detection of benzoic acid, indicating potential applications in material science and chemistry industry quality assurance (Pei et al., 2020).

Chemical Synthesis

Richter et al. (2021) characterized 2-chloro-3-nitro-5-(trifluoromethyl)benzoic acid and -benzamide, precursors for synthesizing benzothiazinones, highlighting their importance in chemical synthesis for medical applications (Richter et al., 2021).

Analytical Chemistry

Barchańska et al. (2019) utilized LC-MS/MS to study the degradation processes of nitisinone, involving 2-(Trifluoromethyl)benzoic acid as a degradation product, demonstrating its relevance in analytical chemistry (Barchańska et al., 2019) .

Environmental Applications

Velegraki and Mantzavinos (2008) explored the photocatalytic degradation of benzoic acid in water, indicating potential environmental applications in water treatment and pollution control (Velegraki & Mantzavinos, 2008).

Safety And Hazards

2-(Trifluoromethyl)benzoic acid may cause skin irritation, serious eye irritation, and respiratory irritation. It is recommended to wear personal protective equipment, ensure adequate ventilation, avoid getting it in eyes, on skin, or on clothing, and avoid ingestion and inhalation.

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Uses