443-88-9 | 2,6-Dimethylfluorobenzene

CAS:443-88-9 | 2,6-Dimethylfluorobenzene,Description

The compound 2-Fluoro-1,3-dimethylbenzene, while not directly synthesized or analyzed in the provided papers, is related to various substituted benzene derivatives that have been studied. These derivatives include compounds with fluorine substitutions and additional functional groups, which can provide insight into the behavior and properties of halogenated aromatic compounds.

Synthesis Analysis

The synthesis of halogenated benzene derivatives is a topic of interest in several studies. For instance, 1,4-bis(dimesitylphosphino)-2,3,5,6-tetrafluorobenzene was synthesized through aromatic nucleophilic substitution, which could be a relevant method for synthesizing 2-Fluoro-1,3-dimethylbenzene. Similarly, 1-Fluoro-2,5-dimethoxy-4-nitrobenzene was produced in high yield by reacting a commercially available dimethoxybenzene with nitric acid, demonstrating the feasibility of direct substitution reactions on the benzene ring. These methods could potentially be adapted for the synthesis of 2-Fluoro-1,3-dimethylbenzene by choosing appropriate starting materials and reaction conditions.

Molecular Structure Analysis

The molecular structure of fluorinated benzene derivatives is often confirmed using X-ray crystallography, as seen in the synthesis of 1-Fluoro-2,5-dimethoxy-4-nitrobenzene. Additionally, the study of molecular pair analysis in the crystal structure of fluorobenzene provides insights into the intermolecular interactions, such as C-H...F, which could also be relevant for understanding the structure of 2-Fluoro-1,3-dimethylbenzene.

Chemical Reactions Analysis

The reactivity of fluorinated benzene derivatives can be complex. For example, the treatment of trimethoxybenzene with an electrophilic fluorinating agent resulted in the formation of 2-fluoro-1,3,5-trimethoxybenzene, indicating that electrophilic substitution can be a viable pathway for introducing fluorine into the benzene ring. This suggests that similar electrophilic fluorination could be applied to synthesize 2-Fluoro-1,3-dimethylbenzene from a dimethylbenzene precursor.

Physical and Chemical Properties Analysis

The physical and chemical properties of fluorinated benzene derivatives are influenced by the presence of the fluorine atom. For instance, the redox properties of bis(phosphoryl)benzene derivatives were investigated through electrochemical measurements, which could be relevant for understanding the electronic properties of 2-Fluoro-1,3-dimethylbenzene. The study of 1-Fluoro-2,5-dimethoxy-4-nitrobenzene also provided characterization through NMR, elemental analysis, and FT-IR, which are standard techniques for determining the properties of organic compounds.

Scientific Research Applications

• Summary of the Application : 2-Fluoro-1,3-dimethylbenzene has been used in the development of a differential fluorescent marking (DFM) strategy for tracking synthetic communities and assembly dynamics in microbiome research.
• Methods of Application or Experimental Procedures : The DFM strategy employs three distinguishable fluorescent proteins in single and double combinations. It is built using the pTn7-SCOUT plasmid family, which allows for modular assembly and facilitates the interchangeability of expression and antibiotic cassettes in a single reaction.
• Results or Outcomes : The DFM strategy has been successfully used to differentiate, quantify, and track a diverse six-member synthetic community (SynCom) under various complex conditions like root rhizosphere.

Safety And Hazards

“2-Fluoro-1,3-dimethylbenzene” is classified as a flammable liquid (Category 3), with a hazard statement of H226. It is recommended to keep away from heat, sparks, open flames, and hot surfaces. Personal protective equipment such as dust masks, eyeshields, and gloves should be used when handling this compound.

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