455-00-5 | 2,6-Bis(trifluoromethyl)pyridine

CAS:455-00-5 | 2,6-Bis(trifluoromethyl)pyridine ,Description

2,6-Bis(trifluoromethyl)pyridine (2,6-BTMP) is a trifluoromethylated pyridine derivative that has been widely studied for its various applications in the field of organic synthesis. It is a versatile reagent that can be used for a variety of synthetic transformations. It is also known for its unique properties such as its high reactivity, low toxicity, and low cost. In addition, 2,6-BTMP has been widely used in the synthesis of drugs, agrochemicals, and other organic compounds.
 

Scientific Research Applications

Coordination Chemistry and Metal Complex Synthesis

2,6-Bis(trifluoromethyl)pyridine and its derivatives have been extensively studied for their role in coordination chemistry. Boča, Jameson, and Linert (2011) reviewed the chemistry of compounds containing pyridine-2,6-diylbis derivatives, highlighting their preparation, properties, and complex compounds formation with metals, showcasing their diverse spectroscopic, structural, magnetic properties, and biological activity. This review identifies potential areas for future research, including the investigation of unknown analogues (Boča, Jameson, & Linert, 2011) .

Organic Synthesis and Catalysis

Pyridine-based compounds, including 2,6-Bis(trifluoromethyl)pyridine, play crucial roles in organic synthesis and catalysis. Guan et al. (2016) discussed the significance of pyridine-based agrochemicals, elucidating the methods enhancing the efficiency of discovering novel lead compounds in the agrochemical field through Intermediate Derivatization Methods. This approach offers insights into novel methods for discovering agrochemicals and pharmaceuticals, emphasizing the crucial role of pyridine derivatives (Guan et al., 2016).

Spectroscopic and Structural Properties

The spectroscopic and structural properties of pyridine derivatives are of significant interest. Pfeifer, Freude, and Hunger (1985) provided a comprehensive review on the acidity of zeolites and related catalysts using nuclear magnetic resonance techniques, including studies on pyridine loaded H-Y zeolites. This research sheds light on the microdynamical model for the pyridine-loaded H-Y zeolites, contributing to a deeper understanding of the interaction between pyridine derivatives and zeolite catalysts (Pfeifer, Freude, & Hunger, 1985).

Environmental and Biological Applications

Environmental and biological applications of pyridine derivatives are explored through the lens of emerging contaminants and potential anticancer agents. Wang et al. (2020) reviewed the environmental occurrence, exposure, and risks of tris(1,3-dichloro-2-propyl)phosphate (TDCPP), highlighting its widespread use and the concerns regarding human health effects. This review emphasizes the importance of understanding the environmental behavior and health risks of emerging contaminants like TDCPP (Wang et al., 2020).

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