455-24-3 | 4-(Trifluoromethyl)benzoic acid

CAS:455-24-3 | 4-(Trifluoromethyl)benzoic acid,Description

4-(Trifluoromethyl)benzoic acid is a benzoic acid carrying a 4-trifluoromethyl substituent. It is a white to light yellow crystal powder. It is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis Analysis

4-(Trifluoromethyl)benzoic acid was used in the synthesis of salicylanilide 4-(trifluoromethyl)benzoates via N,N′-dicyclohexylcarbodiimide coupling in dry N,N-dimethylformamide.

Molecular Structure Analysis

The molecular formula of 4-(Trifluoromethyl)benzoic acid is C8H5F3O2. The molecular weight is 190.12.

Chemical Reactions Analysis

4-(Trifluoromethyl)benzoic acid was used as an internal standard during the ultra trace analysis of fluorinated aromatic carboxylic acids by GC/MS method.

Physical And Chemical Properties Analysis

4-(Trifluoromethyl)benzoic acid is a white powder. Its melting point is 219-220 °C (lit.). The density is 1.4±0.1 g/cm3. The boiling point is 243.2±40.0 °C at 760 mmHg.

Scientific Research Applications

Application 1: Synthesis of Salicylanilide 4-(Trifluoromethyl)benzoates 

• Summary of the Application : 4-(Trifluoromethyl)benzoic acid is used in the synthesis of salicylanilide 4-(trifluoromethyl)benzoates. Salicylanilides are a class of compounds known for their biological activities, including antimicrobial, antiviral, and anticancer properties.
• Methods of Application or Experimental Procedures : The synthesis involves N,N’-dicyclohexylcarbodiimide coupling in dry N,N-dimethylformamide. The specific technical details or parameters of the synthesis would depend on the specific salicylanilide being synthesized.
• Results or Outcomes : The result of this application is the successful synthesis of salicylanilide 4-(trifluoromethyl)benzoates. Quantitative data or statistical analyses would depend on the specific experiment and are not provided in the sources.

Application 2: Ultra Trace Analysis of Fluorinated Aromatic Carboxylic Acids 

• Summary of the Application : 4-(Trifluoromethyl)benzoic acid is used as an internal standard during the ultra trace analysis of fluorinated aromatic carboxylic acids by GC/MS method.
• Methods of Application or Experimental Procedures : The compound is used as an internal standard in a Gas Chromatography/Mass Spectrometry (GC/MS) method. The specific technical details or parameters would depend on the specific GC/MS method being used.
• Results or Outcomes : The result of this application is the successful ultra trace analysis of fluorinated aromatic carboxylic acids. Quantitative data or statistical analyses would depend on the specific experiment and are not provided in the sources.

Safety And Hazards

4-(Trifluoromethyl)benzoic acid may cause respiratory irritation, serious eye irritation, and skin irritation. It is recommended to avoid breathing dust/fume/gas/mist/vapours/spray, avoid contacting with skin and eye, use personal protective equipment, wear chemical impermeable gloves, ensure adequate ventilation, remove all sources of ignition, evacuate personnel to safe areas, and keep people away from and upwind of spill/leak.

Future Directions

4-(Trifluoromethyl)benzoic acid has been used in the synthesis of salicylanilide 4-(trifluoromethyl)benzoates. It has also been used in the regulation of interfaces in perovskite solar cells, improving their power conversion efficiency.

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Uses