459424-38-5 | Fluorocholine

CAS:459424-38-5 | Fluorocholine ,Description

Fluorocholine is a synthetic choline analog that has been used in scientific research for many years, primarily in the fields of biochemistry and physiology. It is a derivative of choline, an essential nutrient for humans, and is used to study the effects of choline on biochemical and physiological processes. Fluorocholine is also known as 1,2-difluoromethylcholine, 1-fluoro-2-methylcholine, 1-fluoro-2-methoxyethylcholine, and 1-fluoro-2-methoxyethyl-trimethyl-ammonium. 
 

Scientific Research Applications

Imaging of Kidney Tumors

Fluorocholine, specifically [18F]fluorocholine, plays a significant role in imaging kidney tumors using positron emission tomography (PET). It is instrumental in monitoring tumor metabolic activity. The research by Visentin et al. (2018) highlights that fluorocholine's uptake in cells is mediated by the organic cation transporter 2 (OCT2). This characteristic is crucial for renal cell carcinoma (RCC) imaging, particularly for increasing detection sensitivity in small metastatic lesions, a major clinical challenge during RCC staging (Visentin et al., 2018).

Prostate Cancer Diagnosis

Fluorocholine has been proven effective in the diagnosis of prostate cancer. Silveira et al. (2016) conducted preclinical studies including acute toxicity, biodistribution, pharmacokinetics, radiation dosimetry, and microPET imaging studies of [(18)F]fluorocholine in mice. These studies support its use in nuclear medicine, particularly in prostate cancer diagnosis (Silveira et al., 2016).

Detection of Prostate Cancer Bone Metastases

Fluorocholine is also crucial in detecting bone metastases in prostate cancer patients. Beheshti et al. (2016) elucidate that 18F-fluorocholine PET/CT is beneficial in the early detection of marrow-based metastases, aiding in evaluating response to hormone therapy and differentiating between degenerative and malignant osseous abnormalities (Beheshti et al., 2016).

Imaging of Brain Tumors

Fluorocholine has diagnostic potential in various cancers, including brain tumors. A case presented by Paudel et al. (2019) showed that fluorocholine PET/CT can reveal intensely tracer-avid lesions in the skull and other skeletal locations, aiding in the diagnosis of plasma cell neoplasm (Paudel et al., 2019).

Differentiation of Hepatic Lesions

In a study by Van den Esschert et al. (2010), PET/CT with 18F-fluorocholine was used to differentiate hepatocellular adenoma (HCA) from focal nodular hyperplasia (FNH). This technique showed promise in distinguishing these hepatic lesions, which is significant for accurate diagnosis and treatment planning (Van den Esschert et al., 2010).

Glioma Characterization

A study by García Vicente et al. (2019) explored the association of metabolic features of F-fluorocholine in gliomas with histopathological and molecular parameters, as well as survival rates. The study found significant correlations, indicating the usefulness of F-fluorocholine PET in predicting tumor biology and patient prognosis in glioma cases (García Vicente et al., 2019).

Troubleshooting in Fluorocholine Synthesis

Vatsa et al. (2018) discussed the challenges and troubleshooting strategies during the synthesis of F-18 fluorocholine, used for imaging various cancers. This study is crucial in understanding the complexities involved in the production of this important radiopharmaceutical (Vatsa et al., 2018).

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