461-17-6 | 1,1,1-Trifluoro-4-iodobutane

CAS:461-17-6 | 1,1,1-Trifluoro-4-iodobutane ,Description

1,1,1-Trifluoro-4-iodobutane, also known as 4-iodobutane-1,1,1-trifluoride, is a fluorinated alkyl iodide with a wide range of applications in scientific research. It is a colorless, volatile liquid with a boiling point of 73.2°C and a melting point of -84.6°C. It is soluble in most organic solvents and is relatively stable in air. It is used in organic synthesis and as a reagent in organic reactions. In addition, it has been used in a variety of biological research applications, including as a probe for the detection of proteins, nucleic acids, and other biological molecules.
 

Scientific Research Applications

• Free Radical Addition in Unsaturated Systems

  • Research has explored the photochemical reactions of compounds like trifluoroiodomethane with unsaturated systems like 1,1,1-trifluorobut-2-ene. These studies found high yields of adducts such as 1,1,1-trifluoro-2-iodo-3-trifluoromethylbutane and 1,1,1-trifluoro-3-iodo-2-trifluoromethylbutane, highlighting the reactivity and potential applications of these fluorinated compounds in chemical synthesis (Gregory, Haszeldine, & Tipping, 1971).

• NMR Studies and Rotational Isomerism

  • NMR (Nuclear Magnetic Resonance) studies have been conducted on various fluorinated compounds, including 1,1,1-trifluoro-4-iodobutane. These studies provide valuable structural information and insights into the rotational isomerism of these molecules, essential for understanding their chemical behavior and potential applications (Shapiro, Lin, & Johnston, 1973).

• Atmospheric Removal Processes

  • The atmospheric lifetimes of hydroiodofluorocarbons (HIFCs), including 1,1,1-trifluoro-4-iodobutane, have been estimated. These studies are crucial for understanding the environmental impact and atmospheric chemistry of these compounds, especially considering their potential as replacements for more harmful substances (Nakano, Shibata, & Watanabe, 2017).

• Chemical Reactivity and Substitution Reactions

  • Research into the chlorination of similar fluorinated compounds, like 1,1,1-trifluoro-2-methylbutane, provides insights into the reactivity and potential for substitution reactions in 1,1,1-trifluoro-4-iodobutane. These studies contribute to a better understanding of the chemical properties and synthesis applications of these molecules (Atto & Tedder, 1982).

• Synthesis of Trifluoromethylated Furan Derivatives

  • The reaction between tert-butyl isocyanide and 1,1,1-trifluoro-4-aryl-butane-2,4-diones, leading to the synthesis of new trifluoromethylated furan derivatives, indicates potential applications in organic synthesis and material science. These derivatives could have various applications, including in pharmaceuticals and advanced materials (Mosslemin, Yavari, Anary‐Abbasinejad, & Nateghi, 2004).

• Photoelectron Spectra Analysis

  • The study of high-resolution photoelectron spectra of various iodoalkanes, including 1,1,1-trifluoro-4-iodobutane, provides important data for electronic structure analysis. Such research is essential for understanding the molecular orbital calculations and electronic properties of these compounds (Boschi & Salahub, 1974).

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