461-18-7 | 4,4,4-Trifluoro-1-butanol

CAS:461-18-7 | 4,4,4-Trifluoro-1-butanol ,Description

4,4,4-Trifluoro-1-butanol (TFB) is a chemical compound that is widely used as a reagent in organic synthesis as well as a solvent for pharmaceutical and industrial processes. It is a colorless, volatile liquid with a sweet, fruity odor. TFB has a low boiling point and is highly flammable, making it a useful reagent for many laboratory experiments. It is also known as trifluorobutanol, trifluorobutanolide, and trifluorobutyl alcohol. 
 

Scientific Research Applications

Conformational Analysis

4,4,4-Trifluoro-1-butanol has been extensively studied for its conformational properties. A study by Lu et al. (2020) explored its rotational spectrum and identified 27 possible geometries. This research is significant for understanding the conformational flexibility of fluorine-containing aliphatic alcohols, which are crucial in solvents for peptides, proteins, and certain chemical reactions.

Synthesis of Enantiomerically Pure Derivatives

Gautschi et al. (1994) focused on synthesizing enantiomerically pure derivatives of 4,4,4-Trifluoro-3-hydroxy-butanoic Acid from 4,4,4-Trifluoro-1-butanol Gautschi, Schweizer, & Seebach, 1994 . These derivatives are vital for various chemical syntheses, emphasizing the importance of 4,4,4-Trifluoro-1-butanol in the production of specialized chemical compounds.

Reactions with Enamines and Imines

Funabiki et al. (2011) demonstrated the synthesis of 4,4,4-trifluoro-1-aryl-3-hydroxy-2-methyl-1-butanones by reacting 4,4,4-Trifluoro-1-butanol derivatives with enamines and imines Funabiki et al., 2011. This research contributes to the field of organic chemistry, particularly in the synthesis of complex organic molecules.

Antimicrobial Activity

Kawase et al. (2001) studied the antimicrobial effects of trifluoromethyl ketones, including derivatives of 4,4,4-Trifluoro-1-butanol. This research found significant antibacterial activity against certain Gram-positive bacteria, highlighting the potential use of 4,4,4-Trifluoro-1-butanol derivatives in antimicrobial applications Kawase et al., 2001.

Proton Transfer in Alcoholic Solvents

Research by Das et al. (1993) explored the proton-transfer processes of certain molecules in the presence of alcoholic solvents, including 4,4,4-Trifluoro-1-butanol Das, Mitra, & Mukherjee, 1993. This study provides insight into the role of fluorinated alcohols in facilitating proton transfer, which is essential in many chemical reactions.

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