461-82-5 | 4-(Trifluoromethoxy)aniline

CAS:461-82-5 | 4-(Trifluoromethoxy)aniline ,Description

4-(Trifluoromethoxy)aniline, also known as 4-TFMA, is an organic compound derived from aniline. It is a colorless liquid with a sweet odor, and is highly soluble in water and organic solvents. 4-TFMA has a wide range of applications in the fields of medicine, chemical synthesis, and environmental protection. It is used as a building block for the synthesis of various organic compounds, and as a reagent in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. Additionally, 4-TFMA is used as an intermediate in the synthesis of various other compounds, such as pharmaceuticals, agrochemicals, and other organic compounds.
 

Scientific Research Applications

Conformational Analysis

A study on the conformational aspects of η6-(4-(trifluoromethoxy)aniline)tricarbonylchromium reveals significant insights. In solid-state, the trifluoromethoxy group is nearly perpendicular to the arene ring, and the amino group is eclipsed by a chromium carbonyl bond. This conformation persists in solution as well (Rose-munch et al., 1994).

Synthesis of Agrochemical Intermediates

4-(Trifluoromethoxy)aniline serves as a precursor for synthesizing important agrochemical intermediates. An improved synthesis process for 2,6-dibromo-4-trifluoromethoxy aniline, derived from 4-trifluoromethoxy aniline, demonstrates high yields and purity, crucial for agrochemical applications (Zhi-yuan, 2011).

Liquid Crystal Applications

Research on 4-trifluoromethyl and 4-trifluoromethoxy derivatives of 4-octyloxy-N-(4-substituted benzylidene) aniline has contributed significantly to liquid crystal technology. These derivatives exhibit stable smectic phases, with the 4-trifluoromethoxy derivative showing a high orientational order in the smectic A phase, highlighting its potential in liquid crystal applications (Miyajima et al., 1995).

Dendrimer Synthesis

In the field of organic materials, 4-(Trifluoromethoxy)aniline plays a role in the synthesis of dendrimers. Its usage in the synthesis and structure of novel G-2 melamine-based dendrimers, incorporating 4-(n-octyloxy)aniline as a peripheral unit, demonstrates its versatility in creating complex organic structures (Morar et al., 2018).

Polymer Synthesis

The chemical has been used in synthesizing side-group liquid-crystalline polymers with fluorine-containing mesogens. Its involvement in creating polymers like polyacrylates and polymethacrylates showcases its utility in advanced materials science (Prescher et al., 1995).

Organic Synthesis

Trifluoromethoxy-substituted anilines, including 4-(Trifluoromethoxy)aniline, are critical in organic synthesis, particularly in reactions involving hydrogen/lithium permutation. This property is exploited for structural elaboration in various organic compounds (Leroux et al., 2003).

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