461-84-7 | 4-(Trifluoromethylthio)phenol

CAS:461-84-7 | 4-(Trifluoromethylthio)phenol ,Description

4-(Trifluoromethylthio)phenol (TFP) is a synthetic compound with a wide range of applications in the scientific and medical fields. It is a colorless, crystalline solid that is insoluble in water but soluble in organic solvents. TFP is a versatile reagent that can be used as a catalyst in a variety of reactions and as a reagent for the synthesis of various compounds. The compound is also used as a protective agent in the production of pharmaceuticals and biocides, and it has been studied for its potential use in cancer therapy. 
 

Scientific Research Applications

Electrophilic Aromatic Ring Trifluoromethylthiolation

The application of 4-(Trifluoromethylthio)phenol in electrophilic aromatic ring trifluoromethylthiolation is notable. This process involves the trifluoromethylthiolation of various substituted phenols, yielding para-substituted SCF3-products. The process is highly para-selective, with estrone and estradiol furnishing biologically interesting SCF3-analogues. Moreover, additional transformations of 4-(Trifluoromethylthio)phenol have led to the creation of bromo-, iodo-, nitro-, and benzyl-substituted products, expanding its utility in synthetic chemistry (Jereb & Gosak, 2015).

Synthesis and Characterization of Copper Phthalocyanine

In another study, a non-peripherally tetra-substituted copper phthalocyanine containing a 4-(Trifluoromethylthio)phenoxy group was synthesized and characterized. The compound's UV-vis spectra, band gap, refractive indices, and surface morphological properties were investigated, demonstrating its potential for various applications including sensing and conductance properties (Günsel et al., 2018) .

Electrochemistry of Phenol in Ionic Liquids

The electrochemistry of phenol in ionic liquids was explored, particularly focusing on the oxidation of phenol and phenolate. This study highlighted the chemical reactions involving phenoxyl radicals and their subsequent transformation into phenyl triflate molecules. This research contributes to our understanding of the electrochemical properties of phenols and their derivatives (Villagrán et al., 2006) .

Synthesis and Properties of Schiff Base Ligands

The synthesis and characterization of Schiff base ligands involving phenols, such as 4-(((4-ethylphenyl)imino)methyl)phenol, were conducted. These compounds demonstrated high corrosion inhibition potential on mild steel surfaces. The study involved various spectroscopic techniques and provided insights into the adsorption and inhibition abilities of these molecules, highlighting their potential in corrosion protection (Elemike et al., 2017).

Phenol Adsorption Studies

Activated carbon fibers were utilized for the adsorption of various phenols from aqueous solutions. This study is significant for understanding the adsorption mechanisms and kinetics of phenols and their derivatives. The research provides valuable information on environmental pollution treatment strategies (Liu et al., 2010).

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