464-05-1 | Pyridine trifluoroacetate

CAS:464-05-1 | Pyridine trifluoroacetate ,Description

Pyridine trifluoroacetate (PTA) is a chemical compound with the molecular formula C6H4F3NO2. It is an organic compound that is used in a variety of laboratory and industrial applications. PTA is a colorless liquid that is soluble in most organic solvents and has a low vapor pressure. It is a strong acid and has a strong odor. PTA is used in the synthesis of pharmaceuticals, agrochemicals, dyes, and other organic compounds. It is also used in the production of polymers, catalysts, and other materials.
 

Scientific Research Applications

Large-Scale Trifluoromethylation

Pyridine trifluoroacetate is used in scalable trifluoromethylation reactions, vital in the pharmaceutical industry. It is employed with pyridine N-oxide derivatives for high-yielding trifluoromethylation, demonstrating utility in preparative applications, including large-scale operations (Beatty et al., 2016).

Organocatalysis in Chemical Synthesis

This compound acts as an effective organocatalyst in asymmetric intramolecular aldol reactions. It has enabled the creation of compounds with high enantioselectivity, particularly in reactions involving aldehyde as a nucleophile and ketone as an electrophile (Hayashi et al., 2007).

Photophysical and Electrochemical Applications

Pyridine trifluoroacetate derivatives are significant in developing materials for organic light-emitting diodes (OLEDs). They exhibit changes in charge transfer upon protonation, impacting optical properties and enabling white photoluminescence and color-tunable emissions in solutions and solid states (Tydlitát et al., 2017) .

X-ray and Infrared Studies in Molecular Structures

It is used in X-ray and FT-IR studies to understand hydrogen bonds in pyridine complexes. This research provides insights into molecular structures and interactions, crucial in various chemical and pharmaceutical applications (Dega-Szafran et al., 1992).

Basicity Studies in Ionic Liquids

The compound is pivotal in studying pyridine basicity in ionic liquids, providing essential data on ion pair formation and the effects of substituents on equilibrium constants. These studies are crucial for understanding chemical interactions in non-aqueous media (Angelini et al., 2010).

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