473-87-0 | 2-fluoropropanedioic Acid

CAS:473-87-0 | 2-fluoropropanedioic Acid ,Description

2-Fluoropropanedioic acid (2-FPA) is a versatile compound with a wide range of applications in the fields of science and technology. It is a colorless, odorless, crystalline solid with a melting point of 115-117 °C. 2-FPA is a carboxylic acid, which is the most common type of organic acid. It is also known as propanedioic acid, fluoropropionic acid, or fluoropropanedioic acid. It is used as a reagent in organic synthesis, as a building block for pharmaceuticals, as an additive in food production, and as a corrosion inhibitor in industrial applications.
 

Scientific Research Applications

Radiopharmaceutical Applications

Fluorine-18 labeled derivatives of 2-fluoropropanedioic acid, such as (2S,4S)-2-[18F]fluoro-4-(phosphonomethyl)pentanedioic acid (BAY 1075553), are being explored in clinical PET studies for the diagnosis and staging of prostate cancer. The development of sensitive analytical methods for characterizing the final product is crucial for its clinical application, including assessing chemical identity, specific activity, and stereoisomer ratio (Graham, Kettschau, Gromov, & Dinkelborg, 2013).

Electrochemistry and Battery Applications

1-Fluoropropane-2-one, a compound related to 2-fluoropropanedioic acid, has been investigated for its effectiveness as an SEI additive in lithium-ion batteries. This compound enhances the first cycle efficiency and stability of batteries, suggesting potential applications in improving the performance of energy storage devices (Krämer, Schmitz, Passerini, Winter, & Schreiner, 2012) .

Cancer Imaging

Fluorinated derivatives of 2-(phosphonomethyl)pentanedioic acid, which include 2-fluoro-4-(phosphonomethyl)pentanedioic acid, have shown promise in prostate cancer imaging. These compounds bind to the prostate specific membrane antigen (PSMA), and their fluorine-substituents are well-tolerated, making them potential candidates for radiolabeled tracers in detecting and staging prostate cancer (Graham et al., 2012).

Synthesis and Resolution of Fluorinated Compounds

Optically active 2-fluoropropanoic acid and its analogs can be synthesized with high enantiomeric purity. This synthesis is crucial for developing fluorine-containing organic molecules, potentially useful in pharmaceutical and chemical industries (Fritz-Langhals & Schu¨tz, 1993).

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