496807-97-7 | 3,3-DIFLUOROPIPERIDINE HYDROCHLORIDE

CAS:496807-97-7 | 3,3-DIFLUOROPIPERIDINE HYDROCHLORIDE,Description

3,3-Difluoropiperidine hydrochloride is a hydrochloride salt of piperidine with two fluoride substituents at the 3-position . It’s a building block used in the synthesis of various compounds .

Molecular Structure Analysis

The molecular formula of 3,3-Difluoropiperidine hydrochloride is C5H9F2N·HCl . The molecular weight is 157.59 g/mol .

Chemical Reactions Analysis

3,3-Difluoropiperidine hydrochloride can be used as a building block in the synthesis of various compounds, including triazole substituted prolyl difluoropyrrolidines as potential inhibitors of dipeptidyl peptidase-4 and dual leucine zipper kinase (DLK) inhibitors .

Physical And Chemical Properties Analysis

3,3-Difluoropiperidine hydrochloride is a solid substance . It has a melting point of 243-247 °C .

Scientific Research Applications

• Organic Synthesis

  • “3,3-Difluoropiperidine hydrochloride” is a type of fluorinated building block , which means it’s likely used in the field of organic chemistry for the synthesis of various compounds . The exact applications, methods of use, and results obtained are not specified in the sources I found .

• Buchwald-Hartwig Amination

  • It appears that “3,3-Difluoropiperidine hydrochloride” might be used in Buchwald-Hartwig Amination . This is a type of chemical reaction used to form carbon-nitrogen bonds . The exact details of this application are not provided in the source .

• Cancer Research

  • There is a mention of “3,3-difluoropiperidine hydrochloride” having an enhanced selectivity of estrogen positive breast cancer . This suggests that it might be used in cancer research, particularly in the study of breast cancer . The exact methods of application and results obtained are not specified in the source .

• NMR Probing

  • “3,3-difluoropiperidine hydrochloride” is also used as a 19 F NMR probe without requiring deuterated solvents or internal standards . This suggests that it might be used in the field of nuclear magnetic resonance (NMR) spectroscopy, a technique used to obtain information about the structure and dynamics of molecules .

• Triazole Substituted Prolyl Difluoropyrrolidines

  • “3,3-Difluoropiperidine hydrochloride” might be used in the synthesis of triazole substituted prolyl difluoropyrrolidines . These compounds could potentially serve as inhibitors of dipeptidyl peptidase-4 , an enzyme that plays a role in glucose metabolism and is a target for the treatment of type 2 diabetes .

• Dual Leucine Zipper Kinase (DLK) Inhibitors

  • It appears that “3,3-Difluoropiperidine hydrochloride” might be used in the synthesis of DLK inhibitors . DLK is a protein kinase involved in neuronal development and degeneration , and inhibitors of this enzyme could potentially be used in the treatment of neurodegenerative diseases .

• Preparation of Cyclic and Acyclic β-Aminofluoroalkenes

  • “3,3-Difluoropiperidine hydrochloride” might be used as a reactant in the preparation of cyclic and acyclic β-aminofluoroalkenes via allylic amination using a palladium catalyst . These compounds could have various applications in medicinal chemistry .

Safety And Hazards

This compound may cause skin and eye irritation, and may be harmful if inhaled . It’s recommended to use personal protective equipment and ensure adequate ventilation when handling this chemical .

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