49713-56-6 | 4-Chloro-6-(trifluoromethyl)quinoline

CAS:49713-56-6 | 4-Chloro-6-(trifluoromethyl)quinoline,Description

4-Chloro-6-(trifluoromethyl)quinoline, also known as 4-Chloro-6-TFM, is an aromatic heterocyclic compound and a member of the quinoline family. It is a colorless solid that is soluble in water and has a molecular weight of 212.55 g/mol. 4-Chloro-6-TFM is a versatile compound that can be used in a variety of scientific applications, including synthesis, research, and laboratory experiments. 
 

Scientific Research Applications

Green Chemistry in Heterocyclic Synthesis

• Solvent- and Catalyst-Free Synthesis : The green chemistry movement has influenced heterocyclic chemistry, leading to the synthesis of compounds like 6H-chromeno[4,3-b]quinolin-6-ones using 4-chloro-3-formylcoumarin without solvents or catalysts. This method is environmentally friendly and avoids toxic by-products and complex separation techniques (Patra, 2021).

Applications in Organic Photovoltaic Devices

• Photovoltaic Properties in Organic–Inorganic Diodes : Quinoline derivatives like 4H-pyrano[3,2-c]quinolines have been used in the fabrication of organic–inorganic photodiode devices. These compounds exhibit photovoltaic properties and are suitable for use as photodiodes (Zeyada, El-Nahass, & El-Shabaan, 2016).

Synthesis of Bioactive Compounds

• Anticancer and Antimicrobial Agents : Quinoline derivatives have been synthesized for biological applications. For example, amino- and fluoro-substituted quinoline-4-carboxylic acid derivatives show significant anticancer activity, while other quinoline derivatives exhibit potent antimicrobial properties (Bhatt, Agrawal, & Patel, 2015); (Eswaran, Adhikari, & Shetty, 2009)(Eswaran, Adhikari, & Shetty, 2009).

Applications in Corrosion Inhibition

• Corrosion Inhibition for Mild Steel : Studies on 4-chloro,8-(trifluoromethyl)quinoline (CTQ) have shown it to be an effective corrosion inhibitor for mild steel in acidic media. This application is crucial for extending the lifespan of metal components in industrial settings (Hebbar, Praveen, Prasanna, & Vishwanath, 2020).

Bioimaging Applications

• Golgi-Localized Probes for Cell Imaging : Quinoline derivatives containing amino and trifluoromethyl groups have been developed for bioimaging, specifically targeting the Golgi apparatus in various cell lines. These compounds offer new avenues in biological imaging and diagnostics (Chen et al., 2019).

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