5042-30-8 | 2,2,2-Trifluoroethylhydrazine

CAS:5042-30-8 | 2,2,2-Trifluoroethylhydrazine ,Description

2,2,2-Trifluoroethylhydrazine (TFEH) is an organic compound with the chemical formula C2H3F3N2. It is a colorless, volatile liquid with a pungent odor. TFEH is a reactive compound and is used as a reagent in organic synthesis and as a propellant in rocket fuel. It has also been used in the production of pharmaceuticals and dyes.
 

Scientific Research Applications

2,2,2-Trifluoroethylhydrazine (TFEH) finds its application in the field of scientific research, particularly in environmental analysis and organic synthesis.

Environmental Analysis

TFEH has been employed as a derivatization reagent in environmental analysis. It reacts with carbonyl compounds to form volatile hydrazones. This property of TFEH makes it suitable for use in methods aimed at detecting and quantifying various carbonyl compounds in environmental samples. For instance, it has been successfully used in the detection of glutaraldehyde in water samples through headspace solid-phase microextraction and gas chromatography–mass spectrometry. The use of TFEH in this context allows for the development of sensitive, rapid, and reliable analytical methods, which are crucial for assessing the hazards of environmental pollutants to living organisms​ ​​ ​.

Organic Synthesis

In the realm of organic synthesis, N-2,2,2-trifluoroethylisatin ketimines, derived from TFEH, have been the subject of significant interest. These compounds are involved in various types of catalytic reactions, such as asymmetric [3 + 2] cycloadditions with different substrates like cinnamaldehydes, nitroalkenes, and methyleneindolinones. These reactions are essential for synthesizing biologically active molecules and developing new methods in synthetic chemistry. The involvement of N-2,2,2-trifluoroethylisatin ketimines in these reactions highlights the utility of TFEH in the synthesis of complex organic molecules, which can have implications for pharmaceuticals and materials science​[“] ​.

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