505084-58-2 | 2-Chloro-5-(trifluoromethyl)isonicotinic acid 97%

CAS:505084-58-2 | 2-Chloro-5-(trifluoromethyl)isonicotinic acid 97%,Description

2-chloro-5-(trifluoromethyl)pyridine is a key structural motif in active agrochemical and pharmaceutical ingredients. It’s a chloro (trifluoromethyl) pyridine.

Synthesis Analysis

The synthesis and applications of trifluoromethylpyridine (TFMP) and its derivatives have been widely used in the agrochemical and pharmaceutical industries. 2-chloro-5-(trifluoromethyl)pyridine (2,5-CTF), a key intermediate for the synthesis of fluazifop, can be obtained in good yield via a simple one-step reaction.

Molecular Structure Analysis

The molecular structure of 2-chloro-5-(trifluoromethyl)pyridine can be found on various chemical databases.

Chemical Reactions Analysis

The major use of TFMP derivatives is in the protection of crops from pests. Various methods of synthesizing 2,3-dichloro-5-(trifluoromethyl)pyridine (2,3,5-DCTF), which is used as a chemical intermediate for the synthesis of several crop-protection products, have been reported.

Physical And Chemical Properties Analysis

The physical properties of 2-chloro-5-(trifluoromethyl)pyridine include a melting point of 32-34 °C (lit.) and a density of 1.417 g/mL at 25 °C (lit.).

Scientific Research Applications

• Agrochemical Industry

  • TFMP derivatives are widely used in the agrochemical industry. The major use of TFMP derivatives is in the protection of crops from pests.
  • Fluazifop-butyl was the first TFMP derivative introduced to the agrochemical market, and since then, more than 20 new TFMP-containing agrochemicals have acquired ISO common names.
  • The biological activities of TFMP derivatives are thought to be due to the combination of the unique physicochemical properties of the fluorine atom and the unique characteristics of the pyridine moiety.

• Pharmaceutical Industry

  • Several TFMP derivatives are also used in the pharmaceutical industry.
  • Five pharmaceutical products containing the TFMP moiety have been granted market approval, and many candidates are currently undergoing clinical trials.
  • The biological activities of TFMP derivatives are thought to be due to the combination of the unique physicochemical properties of the fluorine atom and the unique characteristics of the pyridine moiety.

• Veterinary Industry

  • TFMP derivatives are also used in the veterinary industry.
  • Two veterinary products containing the TFMP moiety have been granted market approval.
  • The biological activities of TFMP derivatives are thought to be due to the combination of the unique physicochemical properties of the fluorine atom and the unique characteristics of the pyridine moiety.

• Synthesis of Metal-Organic Frameworks (MOFs)

  • TFMP derivatives can be used in the synthesis of metal-organic frameworks (MOFs).
  • MOFs are a class of compounds consisting of metal ions or clusters coordinated to organic ligands to form one-, two-, or three-dimensional structures.
  • They are a kind of porous material with potential applications in gas storage, separation, and catalysis.

• Intermediate in Herbicide Synthesis

  • This compound is used as an intermediate in the synthesis of fluazifop-P-butyl and haloxyfop-R-methyl, which are herbicides.
  • Herbicides are substances that are used to control unwanted plants, especially in the growth of crops.

• Intermediate in Insecticide Synthesis

  • It is also used as an intermediate in the synthesis of chlorfluazuron, which is an insecticide.
  • Insecticides are substances used to kill insects, and they play a crucial role in controlling organisms that are harmful to human health.

• Pharmaceutical Intermediate

  • This compound is used as a pharmaceutical intermediate.
  • Pharmaceutical intermediates are the key components in the production of pharmaceuticals.

• Liquid Crystal Intermediate

  • It is used as a liquid crystal intermediate.
  • Liquid crystals find applications in a wide variety of fields, including electronics, optics, and materials science.

• Preparation of (trifluoromethyl)pyridyllithiums

  • This compound can be used in the preparation of (trifluoromethyl)pyridyllithiums via metalation reaction.
  • (Trifluoromethyl)pyridyllithiums are useful reagents in organic synthesis.

• Synthesis of Methiodide Salts

  • It can be used in the synthesis of methiodide salts.
  • Methiodide salts are used in various chemical reactions.

• Intermediate in the Synthesis of Fluazifop-P-butyl and Haloxyfop-R-methyl

  • These compounds are herbicides used for crop protection.
  • Herbicides are substances that are used to control unwanted plants, especially in the growth of crops.

• Intermediate in the Synthesis of Chlorfluazuron

  • Chlorfluazuron is an insecticide.
  • Insecticides are substances used to kill insects. They play a crucial role in controlling organisms that are harmful to human health.

• Pharmaceutical Intermediate

  • This compound is used as a pharmaceutical intermediate.
  • Pharmaceutical intermediates are the key components in the production of pharmaceuticals.

• Liquid Crystal Intermediate

  • It is used as a liquid crystal intermediate.
  • Liquid crystals find applications in a wide variety of fields, including electronics, optics, and materials science.

• Preparation of (Trifluoromethyl)pyridyllithiums

  • This compound can be used in the preparation of (trifluoromethyl)pyridyllithiums via metalation reaction.
  • (Trifluoromethyl)pyridyllithiums are useful reagents in organic synthesis.

• Synthesis of Methiodide Salts

  • It can be used in the synthesis of methiodide salts.
  • Methiodide salts are used in various chemical reactions.

Safety And Hazards

This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200). It may cause skin corrosion/irritation, serious eye damage/eye irritation, and specific target organ toxicity (single exposure). The target organs include the respiratory system. It should be handled in a well-ventilated place, and suitable protective clothing should be worn to avoid contact with skin and eyes.

Future Directions

It is expected that many novel applications of TFMP will be discovered in the future. The development of fluorinated organic chemicals is becoming an increasingly important research topic.

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