51294-16-7 | Perfluoromethyldecalin

CAS:51294-16-7 | Perfluoromethyldecalin ,Description

Perfluoromethyldecalin (PFMD) is a perfluorinated hydrocarbon compound that has been used in a variety of scientific applications due to its unique properties. PFMD is a highly non-polar and hydrophobic compound, with a low vapor pressure, low solubility in water, and a high boiling point. Its chemical structure consists of a central carbon atom surrounded by four fluorine atoms, with a methyl group attached to the central carbon atom. PFMD has been used in a range of scientific applications, including as a solvent for chemical synthesis, as a medium for biochemical and physiological research, and as a stabilizer for lab experiments. In 
 

Scientific Research Applications

Blood Monitoring Applications

A study developed a headspace-gas chromatography-tandem mass spectrometry method for measuring trace levels of perfluorocarbon compounds like perfluoromethyldecalin (PFMD) in blood. This method is essential due to PFMD's oxygen-carrying capabilities, which could potentially be misused in sports doping. The technique allows detection at levels 1000 to 10,000 times lower than the biological effect dose, enabling identification of PFC misuse hours or days post-injection or event. Clinical trials are still needed for validation (Giuliani et al., 2015).

Emulsion Systems

Perfluoromethyldecalin (PFMD) was used to create highly stable emulsions dispersed in a hexagonal liquid crystal phase. The formation of these emulsions offers potential for various applications in fields like material science (Sharma & Warr, 2011).

Catalytic Applications

PFMD solutions were used in the synthesis of fluorous quaternary ammonium salts, which act as phase transfer catalysts for halide substitution reactions in nonpolar fluorous solvents. This demonstrates the potential of PFMD in facilitating chemical reactions in specialized environments (Mandal & Gladysz, 2010).

Environmental Impact Studies

A review focused on the microbial degradation of polyfluoroalkyl chemicals, including PFMD. Understanding their degradation pathways and potential environmental impacts is crucial for evaluating the fate and effects of these chemicals in the environment (Liu & Avendaño, 2013).

Microfluidic Screening and Development Studies

PFMD was used as a carrier liquid in microfluid segments for studying multicellular systems, particularly embryonic development in zebrafish. This application is significant for toxicological and drug screening studies using microfluidic systems (Funfak et al., 2007).

Enhancing Bacterial Growth and Ice-Forming Activity

Perfluoromethyldecalin was studied for its potential to enhance the growth and ice-forming activity of bacteria. The research showed significant increases in biomass and ice-forming activity, indicating a potential application in microbiological studies (Bakulin et al., 2006).

Optical Probes in Biological Applications

A study presented the synthesis and use of Peroxyfluor-1 (PF1), an optical probe for detecting hydrogen peroxide in living cells, utilizing a boronate deprotection mechanism for selectivity. PF1's properties were demonstrated in mammalian cells, showcasing PFMD's role in developing advanced biological tools (Chang et al., 2004).

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