51776-71-7 | 1-Bromo-4-(difluoromethyl)benzene

CAS:51776-71-7 | 1-Bromo-4-(difluoromethyl)benzene ,Description

1-Bromo-4-(difluoromethyl)benzene, also known as 1,4-difluorobromobenzene, is an organic compound with the chemical formula C6H3BrF2. It is a colorless liquid with a sweet odor and is insoluble in water. It is a halogenated aromatic compound and is used in various scientific research applications. 1,4-difluorobromobenzene is commonly used in organic synthesis, as a reagent in organic synthesis, and as a catalyst in chemical reactions.
 

Scientific Research Applications

Fluorescence Properties and Synthesis

1-Bromo-4-(2,2-diphenylvinyl)benzene, a derivative of 1-Bromo-4-(difluoromethyl)benzene, was synthesized using the Wittig-Horner reaction. This compound displayed notable fluorescence properties, particularly in its solid state, demonstrating potential for applications in photoluminescence-based technologies (Liang Zuo-qi, 2015).

Precursor in Graphene Nanoribbon Synthesis

1-Bromo-4-(3,7-dimethyloctyl)benzene, another variant, serves as a precursor in the bottom-up synthesis of planar one-dimensional graphene nanoribbons. These nanoribbons have controlled edge morphology and narrow widths, which are critical for advanced material applications (S. Patil et al., 2012).

Aryne Route to Naphthalenes

Research demonstrated that treating 1-bromo-4-(trifluoromethoxy)benzene with lithium diisopropylamide generates a reactive intermediate, leading to the synthesis of various naphthalenes. This method offers an innovative approach to create complex organic structures (M. Schlosser & E. Castagnetti, 2001).

Organometallic Synthesis

1-Bromo-3,5-bis(trifluoromethyl)benzene, related to 1-Bromo-4-(difluoromethyl)benzene, is utilized as a versatile starting material in organometallic synthesis. Its reactions through various intermediates are useful in creating synthetically valuable compounds (J. Porwisiak & M. Schlosser, 1996).

Radiosynthesis of Labelling Agents

In medical imaging, 1-Bromo-4-(difluoromethyl)benzene derivatives are used in the radiosynthesis of labelling agents. These agents are crucial for developing new imaging techniques in nuclear medicine (V. Namolingam et al., 2001) .

Modular Construction in Dendrimer Synthesis

The compound serves as a building block in the modular construction of dendritic carbosilanes. Its use in sequential convergent and divergent steps is key for synthesizing modified carbosilane dendrimers, important in nanotechnology and materials science (Casado & Stobart, 2000).

Molecular Electronics

1-Bromo-4-(difluoromethyl)benzene derivatives are foundational in the synthesis of thiol end-capped molecular wires for molecular electronics. These wires are pivotal for the development of miniaturized electronic components (N. Stuhr-Hansen et al., 2005).

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