52353-35-2 | 4-CHLORO-2-(TRIFLUOROMETHYL)QUINAZOLINE

CAS:52353-35-2 | 4-CHLORO-2-(TRIFLUOROMETHYL)QUINAZOLINE,Description

4-Chloro-2-(trifluoromethyl)quinazoline, or 4-CQ, is an organic compound with a trifluoromethyl group attached to the quinazoline ring. This compound has been studied for its potential applications in medicinal chemistry, organic synthesis, and drug discovery. 4-CQ has been found to be a potent inhibitor of several enzymes, including tyrosine kinases, cytochrome P450 enzymes, and proteases. It also has been studied for its ability to modulate cell signaling pathways. 
 

Scientific Research Applications

Application 1: Anticancer Agents

• Scientific Field : Medicinal Chemistry, Oncology.
• Summary of the Application : 4-Chloro-2-(trifluoromethyl)quinazoline is used in the design and synthesis of N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives, which are potential Werner (WRN) helicase inhibitors. These compounds have shown significant anticancer activities against various cancer cell lines.
• Methods of Application or Experimental Procedures : A series of N-aryl-2-trifluoromethyl-quinazoline-4-amine derivatives were designed and synthesized through a structural optimization strategy. The anticancer activities of these new target compounds were evaluated against PC3, K562, and HeLa cell lines using the MTT assay.
• Results or Outcomes : Some of these compounds exhibited excellent inhibitory activity against three different cancer cell lines. Compounds 6a, 8i, and 13a showed better antiproliferative activity against K562 cells, with IC50 values of 3871.5, 613.6 and 134.7 nM, respectively. Further study demonstrated that among the tested compounds, 13a was the most sensitive to PC3-WRN.

Application 2: Antimicrobial Agents

• Scientific Field : Medicinal Chemistry, Microbiology.
• Summary of the Application : 4-Chloro-2-(trifluoromethyl)quinazoline is used in the synthesis of quinazolinone derivatives, which have shown significant antimicrobial activities.
• Methods of Application or Experimental Procedures : Quinazolinone derivatives were synthesized by treating 2-chloro-N-(4-oxo-2-phenylquinazolin-3(4H)-yl)acetamide with different substituted phenols. The synthesized compounds were evaluated for antibacterial activity by the cup plate method.
• Results or Outcomes : The synthesized compounds showed promising antibacterial activity.

Application 3: Antioxidant Agents

• Scientific Field : Medicinal Chemistry, Biochemistry.
• Summary of the Application : 4-Chloro-2-(trifluoromethyl)quinazoline is used in the synthesis of quinazoline derivatives, which have shown significant antioxidant activities.
• Methods of Application or Experimental Procedures : Quinazoline derivatives were synthesized and their antioxidant activities were evaluated.
• Results or Outcomes : The synthesized compounds showed promising antioxidant activity.

Application 4: Antifungal Agents

• Scientific Field : Medicinal Chemistry, Mycology.
• Summary of the Application : 4-Chloro-2-(trifluoromethyl)quinazoline is used in the synthesis of quinazoline derivatives, which have shown significant antifungal activities.
• Methods of Application or Experimental Procedures : Quinazoline derivatives were synthesized and their antifungal activities were evaluated.
• Results or Outcomes : The synthesized compounds showed promising antifungal activity.

Application 5: Antiviral Agents

• Scientific Field : Medicinal Chemistry, Virology.
• Summary of the Application : 4-Chloro-2-(trifluoromethyl)quinazoline is used in the synthesis of quinazoline derivatives, which have shown significant antiviral activities.
• Methods of Application or Experimental Procedures : Quinazoline derivatives were synthesized and their antiviral activities were evaluated.
• Results or Outcomes : The synthesized compounds showed promising antiviral activity.

Application 6: Antidiabetic Agents

• Scientific Field : Medicinal Chemistry, Endocrinology.
• Summary of the Application : 4-Chloro-2-(trifluoromethyl)quinazoline is used in the synthesis of quinazoline derivatives, which have shown significant antidiabetic activities.
• Methods of Application or Experimental Procedures : Quinazoline derivatives were synthesized and their antidiabetic activities were evaluated.
• Results or Outcomes : The synthesized compounds showed promising antidiabetic activity.

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