Purchase CAS:54-20-6,view related peer-reviewed papers,technical documents,similar products,MSDS & more. Trifluorothymidine (TFT) is an antiviral agent that is used in the treatment of viral infections. It is an analog of thymidine, a nucleoside found in DNA and RNA. TFT is used in the laboratory to study the effects of antiviral drugs on viral replication and the mechanism of action of antiviral drugs. TFT has been used ...
Trifluorothymidine (TFT) is an antiviral agent that is used in the treatment of viral infections. It is an analog of thymidine, a nucleoside found in DNA and RNA. TFT is used in the laboratory to study the effects of antiviral drugs on viral replication and the mechanism of action of antiviral drugs. TFT has been used in clinical trials for the treatment of HIV and other viral infections.
Scientific Research Applications
Molecular Structure and Vibrational Spectrum Analysis: Trifluorothymine's molecular structure and its vibrational spectrum were thoroughly investigated, revealing insights into its potential as an antitumor and antiviral agent. Experimental and theoretical spectra were compared, and the effects of intermolecular hydrogen bonding were evaluated (Çırak & Koç, 2012) .
Applications in Organic Synthesis: Though not directly focused on trifluorothymine, studies have highlighted the use of trifluoromethanesulfonate in organic synthesis, which can be relevant for understanding the broader category of trifluoromethyl compounds, including trifluorothymine (Ishihara et al., 1996).
Role in Medicinal Chemistry: Trifluoromethoxy group, a close relative of trifluorothymine, has significant applications in medicinal chemistry, particularly in the development of analgesics, cardiovascular drugs, and anti-infective therapeutics (Jeschke, Baston, & Leroux, 2007).
Crystal and Molecular Structure in Metabolites: The crystal structure of 5-trifluorothymine from human urine was determined, providing insights into the role of fluorine in stacking and hydrogen-bonded interactions, which is crucial for understanding its biological interactions (Rajeswaran & Srikrishnan, 2008).
Metabolism in Therapeutic Contexts: The metabolism of 5-trifluoromethyl-2′-deoxythymidine, closely related to trifluorothymine, was studied in mice. This research is essential for understanding how trifluorothymine-related compounds behave in biological systems, especially for therapeutic applications (Tandon, Kumar, & Wiebe, 1993).
Clinical Pharmacology in Cancer Research: Clinical pharmacological studies of trifluorothymidine, a compound structurally similar to trifluorothymine, were conducted on patients with advanced cancer, providing critical data on its metabolism and potential therapeutic efficacy (Dexter et al., 1972).