55258-76-9 | 4-ETHYL-2-FLUORO-1,1'-BIPHENYL

CAS:55258-76-9 | 4-ETHYL-2-FLUORO-1,1'-BIPHENYL,Description

4-Ethyl-2-fluoro-1,1’-biphenyl is an organic compound. It is also known as Flurbiprofen EP Impurity. It appears as a colorless crystal or white powder.

Synthesis Analysis

The synthesis of compounds similar to 4-Ethyl-2-fluoro-1,1’-biphenyl has been reported in the literature. For instance, (±)-N-(1,2-Bis(3,4-dimethoxyphenyl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide was obtained for the first time from 1,2-bis(3,4-dimethoxyphenyl)ethan-1-amine and (±)-flurbiprofen in one step.

Molecular Structure Analysis

The molecular formula of 4-Ethyl-2-fluoro-1,1’-biphenyl is C14H13F. Its molecular weight is 200.25 g/mol.

Physical And Chemical Properties Analysis

4-Ethyl-2-fluoro-1,1’-biphenyl is a crystalline solid that is white to light brown in color. It is insoluble in water but soluble in organic solvents such as acetone, chloroform, and ethyl acetate.

Scientific Research Applications

Application in the Synthesis of Bio-functional Hybrid Compounds

• Scientific Field : Organic Chemistry
• Summary of the Application : The compound “4-Ethyl-2-fluoro-1,1’-biphenyl” has been used in the synthesis of a new bio-functional hybrid compound, (±)-N-(1,2-bis(3,4-dimethoxyphenyl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide. This compound was synthesized for the first time from 1,2-bis(3,4-dimethoxyphenyl) ethan-1-amine and (±)-flurbiprofen in one step.
• Methods of Application : The synthesis involved a reaction between 1,2-bis(3,4-dimethoxyphenyl) ethan-1-amine and (±)-flurbiprofen.
• Results or Outcomes : The newly synthesized bio-functional hybrid compound was fully characterized using 1H, 13C-NMR, UV, and mass spectral data.

Application in the Synthesis of SARS-CoV-2 Treatment Trials

• Scientific Field : Medicinal Chemistry
• Summary of the Application : “4-Ethyl-2-fluoro-1,1’-biphenyl” has been used in the synthesis of N-(2-(1H-Indol-3-yl)ethyl)-2-(2-fluoro-[1,1′-biphenyl]-4-yl)propanamide. This compound was prepared by a reaction between tryptamine and flurbiprofen, and it has a fragment similar to Brequinar, a compound used in SARS-CoV-2 treatment trials.
• Methods of Application : The synthesis involved a reaction between tryptamine and flurbiprofen, applying N,N’-Dicyclohexylcarbodiimide, as a coupling agent.
• Results or Outcomes : The newly synthesized compound was fully analyzed and characterized via 1H, 13C-NMR, UV, IR, and mass spectral data.

Application in the Synthesis of Bio-functional Hybrid Compounds

• Scientific Field : Organic Chemistry
• Summary of the Application : “4-Ethyl-2-fluoro-1,1’-biphenyl” has been used in the synthesis of a new bio-functional hybrid compound, 2-(2-fluoro-[1,1′-biphenyl]-4-yl)-N-(1-phenylpropan-2-yl)propanamide. This compound was synthesized by a reaction between amphetamine and flurbiprofen.
• Methods of Application : The synthesis involved a reaction between amphetamine and flurbiprofen.
• Results or Outcomes : The newly synthesized bio-functional hybrid compound was fully characterized using 1H, 13C, UV, IR, HPLC, and mass spectral data.

Application in the Synthesis of Bio-functional Hybrid Compounds

• Scientific Field : Organic Chemistry
• Summary of the Application : “4-Ethyl-2-fluoro-1,1’-biphenyl” has been used in the synthesis of a new bio-functional hybrid compound, 2-(2-fluoro-[1,1′-biphenyl]-4-yl)-N-(4-methyl-2-oxo-2H-chromen-7-yl)propanamide. This compound was synthesized by a reaction between 7-amino-4-methyl-2H-chromen-2-one and flurbiprofen.
• Methods of Application : The synthesis involved a reaction between 7-amino-4-methyl-2H-chromen-2-one and flurbiprofen.
• Results or Outcomes : The newly synthesized bio-functional hybrid compound was fully characterized using 1H, 13C NMR, UV, and mass spectral data.

Application in the Synthesis of Bio-functional Hybrid Compounds

• Scientific Field : Organic Chemistry
• Summary of the Application : “4-Ethyl-2-fluoro-1,1’-biphenyl” has been used in the synthesis of a new bio-functional hybrid compound, 2-(2-fluoro-[1,1′-biphenyl]-4-yl)-N-(1-phenylpropan-2-yl)propanamide. This compound was synthesized by a reaction between amphetamine and flurbiprofen.
• Methods of Application : The synthesis involved a reaction between amphetamine and flurbiprofen.
• Results or Outcomes : The newly obtained hybrid molecule was fully analyzed and characterized via 1H, 13C, UV, IR, HPLC, and mass spectral data.

Application in the Synthesis of Bio-functional Hybrid Compounds

• Scientific Field : Organic Chemistry
• Summary of the Application : “4-Ethyl-2-fluoro-1,1’-biphenyl” has been used in the synthesis of a new bio-functional hybrid compound, 2-(2-fluoro-[1,1′-biphenyl]-4-yl)-N-(4-methyl-2-oxo-2H-chromen-7-yl)propanamide. This compound was synthesized by a reaction between 7-amino-4-methyl-2H-chromen-2-one and flurbiprofen.
• Methods of Application : The synthesis involved a reaction between 7-amino-4-methyl-2H-chromen-2-one and flurbiprofen.
• Results or Outcomes : The newly synthesized bio-functional hybrid compound was fully characterized using 1H, 13C NMR, UV, and mass spectral data.

Safety And Hazards

According to the Safety Data Sheet, it is advised to use chemical impermeable gloves when handling 4-Ethyl-2-fluoro-1,1’-biphenyl. Ensure adequate ventilation and remove all sources of ignition. It is also recommended to prevent the chemical from entering drains.

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