58201-66-4 | (Bromodifluoromethyl)triphenylphosphonium bromide

CAS:58201-66-4 | (Bromodifluoromethyl)triphenylphosphonium bromide ,Description

(Bromodifluoromethyl)triphenylphosphonium bromide (abbreviated as BDFPPB) is a type of quaternary ammonium compound (QAC) that is used in a variety of scientific research applications. BDFPPB is a synthetic compound that is composed of bromine, fluorine, methyl, and triphenylphosphonium. It is a highly potent and versatile compound that has been used in a variety of applications, including drug synthesis, nanomaterials, and biochemistry. 
 

Scientific Research Applications

Photoredox Catalysis

One application involves the use of (bromodifluoromethyl)triphenylphosphonium bromide in photoredox catalysis. This compound acts as a precursor for the CF2H radical in the bromodifluoromethylation of alkenes under visible-light conditions, facilitating selective formation of bromodifluoromethylated products (Lin et al., 2016).

Crystal Structure Analysis

Another research application is in crystal structure analysis. (Bromodifluoromethyl)triphenylphosphonium bromide has been studied for its crystalline structure, providing insights into molecular configurations and interactions (Bender et al., 2000).

Organic Synthesis

In the field of organic synthesis, this compound has been used for the difluoromethylation of thiols. This process occurs without transition metals, using a stable and accessible phosphonium salt. The broad substrate scope and tolerance for various functional groups make this a versatile tool in synthetic chemistry (Heine & Studer, 2017).

Drug Discovery Applications

The compound's use extends to drug discovery, where hydrodifluoromethylation reactions with alkenes derived from oxindoles are performed. This process creates difluoromethylated oxindoles with C-CF2H quaternary centers, which are potentially valuable in pharmaceutical development (Hu et al., 2018).

Waste Treatment

There's also an application in waste treatment, particularly in removing technetium from radioactive waste streams. The stability and degradation behavior of the compound under different conditions are crucial for ensuring its safe and effective use in this context (Aldridge et al., 2007).

Polymer Chemistry

In polymer chemistry, (bromodifluoromethyl)triphenylphosphonium bromide has been utilized for the modification of polymers, enhancing their functionality and utility in various applications (Hassanein et al., 1989).

Supramolecular Chemistry

This compound plays a role in supramolecular chemistry. Its use in the formation of hydrogels from vesicles highlights its potential in the development of smart materials and biochemical applications (Li et al., 2013).

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