58656-04-5 | TRICYCLOHEXYLPHOSPHONIUM TETRAFLUOROBORATE

CAS:58656-04-5 | TRICYCLOHEXYLPHOSPHONIUM TETRAFLUOROBORATE,Description

Tricyclohexylphosphonium tetrafluoroborate, also known as Tricyclohexylphosphine tetrafluoroborate (PCy 3 ·HBF 4), is an inexpensive and air-stable phosphine ligand. It is commonly used in cross-coupling reactions.

Molecular Structure Analysis

The linear formula for Tricyclohexylphosphonium tetrafluoroborate is (C6H11)3P · HBF4. The molecular weight is 368.24.

Chemical Reactions Analysis

Tricyclohexylphosphonium tetrafluoroborate is used with ruthenium (1,5-cyclooctadiene)ruthenium dimer to catalyze the dehydrogenative coupling of alcohols and amines to form amide bonds. It is also used in Suzuki reactions.

Physical And Chemical Properties Analysis

Tricyclohexylphosphonium tetrafluoroborate is a solid substance. It has a melting point of 164 °C.

Scientific Research Applications

1. Dehydrogenative Coupling of Alcohols and Amines to Form Amide Bonds

• Summary of Application : Tricyclohexylphosphonium tetrafluoroborate is used with ruthenium (1,5-cyclooctadiene)ruthenium dimer to catalyze the dehydrogenative coupling of alcohols and amines to form amide bonds.
• Results or Outcomes : The outcome of this reaction is the formation of amide bonds. The source does not provide any quantitative data or statistical analyses.

2. Suzuki Reaction

• Summary of Application : Tricyclohexylphosphonium tetrafluoroborate is also used in the Suzuki reaction.
• Results or Outcomes : The outcome of this reaction is the formation of a carbon-carbon bond. The source does not provide any quantitative data or statistical analyses.

3. Preparation of C-homoaporphine Alkaloids

• Summary of Application : Tricyclohexylphosphonium tetrafluoroborate is used as a ligand for preparing C-homoaporphine alkaloids via microwave-assisted direct-arylation.
• Results or Outcomes : The outcome of this reaction is the formation of C-homoaporphine alkaloids. The source does not provide any quantitative data or statistical analyses.

Safety And Hazards

Tricyclohexylphosphonium tetrafluoroborate is harmful if swallowed, in contact with skin, or if inhaled. It is recommended to wear protective gloves, clothing, eye protection, and face protection when handling this compound. In case of skin contact, wash with plenty of soap and water. If swallowed, call a poison center or doctor/physician.

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