60839-94-3 | Fluoromethyl phenyl sulfide

CAS:60839-94-3 | Fluoromethyl phenyl sulfide ,Description

Fluoromethyl phenyl sulfide (FMPS) is a chemical compound that has gained attention in scientific research due to its potential applications in various fields, including medicine, agriculture, and industry. FMPS is a sulfide compound with a molecular formula of C7H7FS. It is a colorless liquid with a distinctive odor and is soluble in organic solvents such as chloroform and benzene.
 

Scientific Research Applications

Synthesis of Fluoroalkenes

Fluoromethyl phenyl sulfide is a significant intermediate in the synthesis of fluoroalkenes. It's involved in reactions with diethylaminosulfur trifluoride to produce fluoromethyl phenyl sulfone, a key reagent in this process. These reactions are integral in halogenation and fluorination processes, contributing to advancements in organic synthesis (J. McCarthy, D. Matthews, J. Paolini, 2003).

Facilitating Synthesis of α-Monofluoromethyl Alcohols

The compound plays a pivotal role in the nucleophilic monofluoromethylations of aldehydes, using derivatives like fluoromethyl phenyl sulfone or fluorobis(sulfonyl)methanes. It's part of a synthetic approach toward β-monofluorinated alcohols, enhancing the versatility and efficiency of fluoroorganic compound synthesis (G. Prakash, Nana Shao, Zhe Zhang, C. Ni, F. Wang, R. Haiges, G. Olah, 2012) .

Production of Fluoromethylketones

Fluoromethyl phenyl sulfoxide has been utilized in the production of fluoromethylketones and vinyl fluorides. This involves reactions like alkylation and pyrolysis, demonstrating the compound's utility in creating diverse organic molecules, particularly in the field of organic chemistry and material science (V. Reutrakul, V. Rukachaisirikul, 1983).

Designing Fluorescent Probes

In the design of fluorescent probes for bioimaging, fluoromethyl phenyl sulfide derivatives have been employed. They are crucial in developing probes for detecting small biomolecules, demonstrating the compound's application in biomedical research and diagnostic imaging (Xiao-yan Zhu, Hao Wu, Xiaofeng Guo, Hong Wang, 2019).

Electrophilic Fluoromethylating Reagent

The compound has been explored as a component in creating novel electrophilic fluoromethylating protocols. These protocols have enhanced reactivity towards a variety of nucleophilic species, yielding difluoromethylated products. This application signifies its importance in synthetic chemistry for generating fluoroalkylated compounds (G. Prakash, Zhe Zhang, F. Wang, C. Ni, G. Olah, 2011).

More Information